Abstract：
Fatal drug overdoses among pregnant and postpartum individuals have risen dramatically over the past 10 years. Trends in and characteristics of nonfatal drug overdoses in this population, however, remain unknown, despite the importance of this outcome for maternal and infant health. We used statewide, longitudinally-linked hospital and emergency department administrative claims data from California to characterize the incidence, trends, drug type involvement, and sociodemographic disparities in pregnancy-associated drug overdose between 2010 and 2019. Generalized linear models accounting for multiple deliveries per individual were used to test for trends; descriptive statistics were used for other study analyses. Of California individuals with a live delivery between 2010 and 2018, approximately 0.2% had a pregnancy-associated drug overdose. Nonfatal overdoses were nearly 60 times more common than fatal overdoses. Incidence of overdoses involving stimulants increased in frequency, while incidence of overdoses involving sedative/hypnotic drugs and psychotropic medications decreased in frequency. Risk of overdose was substantially higher among delivering individuals who were young, non-Hispanic Black, Medicaid patients, or who lived in non-metropolitan areas. Ongoing public health surveillance of and clinical interventions to reduce pregnancy-associated nonfatal drug overdose events are critical for prevention efforts.
摘要：
在过去的10年中，孕妇和产后个体的致命药物过量急剧增加。该人群非致命药物过量的趋势和特征，然而,仍然未知，尽管这一结果对母婴健康很重要。我们在全州范围内使用，来自加利福尼亚州的纵向联系医院和急诊科的行政索赔数据来表征发病率，趋势,药物类型参与，2010年至2019年期间妊娠相关药物过量的社会人口统计学差异。使用解释每个个体多次交付的广义线性模型来测试趋势；描述性统计用于其他研究分析。在2010年至2018年期间进行现场分娩的加利福尼亚州个体中，约有0.2％的人患有与怀孕相关的药物过量。非致命性用药过量的发生率是致命性用药过量的近60倍。涉及兴奋剂的过量发生率增加，而涉及镇静/催眠药物和精神药物的过量发生率下降。在年轻的分娩个体中，服药过量的风险高得多，非西班牙裔黑人,医疗补助患者,或者住在非大都市地区的人。持续的公共卫生监测和临床干预以减少与妊娠相关的非致命药物过量事件对于预防工作至关重要。
