Language Therapy

语言治疗
  • 文章类型: Journal Article
    背景:失聪或听力困难(DHH)的儿童有言语和语言延迟的风险。来自较低社会经济背景的DHH儿童的语言结果更差,部分原因是在获得专门的言语语言治疗方面存在差异。远程治疗可能有助于改善获得这种专业护理的机会,并缩小这种语言差距。将不同的DHH儿童纳入前瞻性随机临床试验一直具有挑战性,但对于解决差异和追求听力健康公平是必要的。利益相关者关于研究设计元素决策的输入,包括比较组,掩蔽,评估和补偿,设计包容性研究是必要的。我们设计了一个包容性的,解决儿科听力健康差异的公平比较有效性试验。该研究的具体目的是确定获得和利用言语远程治疗在解决DHH低收入儿童的语言差异方面的效果。
    方法:在利益相关者输入和试点数据收集之后,我们设计了一项随机临床试验和并行纵向队列试验,在美国4家三级儿童医院进行.参与者将包括210名0-27个月的DHH儿童。其中140个孩子将来自低收入家庭,他们将被随机分配1:1接受常规治疗,而不是常规治疗,并获得补充的言语语言远程治疗。将同时招募70名来自高收入家庭的儿童作为比较队列。主要结果测量将是学前语言量表听觉理解子量表标准分数,加上额外的演讲,语言,听力和生活质量验证指标作为次要结局.
    背景:这项研究得到了参与研究的机构审查委员会的批准:加州大学,旧金山(19-28356)拉迪儿童医院(804651)和西雅图儿童医院(STUDY00003750)。注册儿童的父母将为他们的孩子的参与提供书面知情同意书。参与整个研究设计的专业和家长利益相关者团体将通过出版物以及国家和区域组织促进研究结果的传播和实施。
    背景:NCT04928209。
    BACKGROUND: Children who are deaf or hard-of-hearing (DHH) are at risk for speech and language delay. Language outcomes are worse in DHH children from lower socioeconomic backgrounds, due in part to disparities in access to specialised speech-language therapy. Teletherapy may help improve access to this specialised care and close this language gap. Inclusion of diverse DHH children in prospective randomised clinical trials has been challenging but is necessary to address disparities and pursue hearing health equity. Stakeholder input regarding decisions on study design elements, including comparator groups, masking, assessments and compensation, is necessary to design inclusive studies. We have designed an inclusive, equitable comparativeness effectiveness trial to address disparities in paediatric hearing health. The specific aims of the study are to determine the effect of access to and utilisation of speech-language teletherapy in addressing language disparities in low-income children who are DHH.
    METHODS: After stakeholder input and pilot data collection, we designed a randomised clinical trial and concurrent longitudinal cohort trial to be conducted at four tertiary children\'s hospitals in the USA. Participants will include 210 DHH children aged 0-27 months. 140 of these children will be from lower income households, who will be randomised 1:1 to receive usual care versus usual care plus access to supplemental speech-language teletherapy. 70 children from higher income households will be simultaneously recruited as a comparison cohort. Primary outcome measure will be the Preschool Language Scales Auditory Comprehension subscale standard score, with additional speech, language, hearing and quality of life validated measures as secondary outcomes.
    BACKGROUND: This study was approved by the Institutional Review Boards of the participating sites: the University of California, San Francisco (19-28356), Rady Children\'s Hospital (804651) and Seattle Children\'s Hospital (STUDY00003750). Parents of enrolled children will provide written informed consent for their child\'s participation. Professional and parent stakeholder groups that have been involved throughout the study design will facilitate dissemination and implementation of study findings via publication and through national and regional organisations.
    BACKGROUND: NCT04928209.
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  • 文章类型: Journal Article
    帕金森病(PD)患者会出现一系列进行性运动和非运动症状,对他们的日常运作产生负面影响,社会参与和生活质量。联合健康疗法已成为一种有效的治疗方法-补充药理学和神经外科治疗-减少了PD在日常生活中的影响。在这篇文章中,我们为PD的专业专职医疗提出了标准,我们从符合这些标准的角度回顾了PD中的专职健康研究,并对单学科方法以及多学科或多学科专职健康干预措施的结果进行了回顾。我们专注于PD中研究最多的三个专职健康学科:物理治疗,职业治疗和语言治疗。总的来说,现有证据强调了对PD患者实施专业专职医疗服务的重要性和潜在益处.我们提出的未来研究标准和建议可能有助于进一步界定专业的专职医疗保健。
    People with Parkinson\'s disease (PD) experience a range of progressive motor and non-motor symptoms, that negatively affect their daily functioning, social participation and quality of life. Allied health therapies have emerged as an effective treatment approach-complementary to pharmacological and neurosurgical treatments-which reduces the impact of PD in daily life. In this article, we propose criteria for what constitutes specialized allied health care for PD, and we review allied health research in PD in terms of meeting these criteria and its outcomes for monodisciplinary approaches as well as multi- or interdisciplinary allied health interventions. We focus on the three most studied allied health disciplines in PD: physical therapy, occupational therapy and speech-language therapy. Overall, the available evidence underscores the importance and potential benefits of specialized allied health care for people with PD. Our proposed criteria and recommendations for future research might help in further delineating specialized allied health care.
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  • 文章类型: Journal Article
    这项研究检查了早期儿童环境中的交互检测(IDEAS)的准确性,自动转录音频文件并估计与语言治疗相关的语言单位的程序,包括代表语言复杂性特征的词性单元,如形容词和协调连词。
    使用了45次视频录制的言语语言治疗课程,涉及27名言语语言病理学家(SLP)和56名儿童。F度量确定IDEAS二值化的准确性(即,语音分割和说话人分类)。另外两个评估指标,即,中位数绝对相对误差和相关性,与两个条件相比,表明IDEAS对语言单位估计的准确性,即,Oracle(手动二值化)和语音类型分类器(现有的具有可接受精度的二值化器)。
    SLP谈话数据的高F度量表明,SLP谈话的IDEASdiarization具有很高的准确性,但儿童谈话的准确性较低。这些差异反映在IDEAS语言单位估计的准确性中。IDEAS10个SLP语言单元估计值中有9个的中值绝对相对误差和相关值符合准确性标准,但是儿童语言单位估计都不符合这些标准。语言单位的类型也会影响IDEAS的准确性。
    IDEAS是针对教育环境量身定制的,可以自动将录音转换为文本,并在言语语言治疗课程和课堂环境中提供语言单位估计。虽然不完美,IDEAS在自动捕获和返回语言单位方面是可靠的,尤其是在SLP演讲中,这与研究和实践有关。该工具提供了一种在临床环境中自动测量SLP通话的方法,这将支持旨在了解SLP谈话如何影响儿童语言成长的研究。
    UNASSIGNED: This study examines the accuracy of Interaction Detection in Early Childhood Settings (IDEAS), a program that automatically transcribes audio files and estimates linguistic units relevant to speech-language therapy, including part-of-speech units that represent features of language complexity, such as adjectives and coordinating conjunctions.
    UNASSIGNED: Forty-five video-recorded speech-language therapy sessions involving 27 speech-language pathologists (SLPs) and 56 children were used. The F measure determines the accuracy of IDEAS diarization (i.e., speech segmentation and speaker classification). Two additional evaluation metrics, namely, median absolute relative error and correlation, indicate the accuracy of IDEAS for the estimation of linguistic units as compared with two conditions, namely, Oracle (manual diarization) and Voice Type Classifier (existing diarizer with acceptable accuracy).
    UNASSIGNED: The high F measure for SLP talk data suggests high accuracy of IDEAS diarization for SLP talk but less so for child talk. These differences are reflected in the accuracy of IDEAS linguistic unit estimates. IDEAS median absolute relative error and correlation values for nine of the 10 SLP linguistic unit estimates meet the accuracy criteria, but none of the child linguistic unit estimates meet these criteria. The type of linguistic units also affects IDEAS accuracy.
    UNASSIGNED: IDEAS was tailored to educational settings to automatically convert audio recordings into text and to provide linguistic unit estimates in speech-language therapy sessions and classroom settings. Although not perfect, IDEAS is reliable in automatically capturing and returning linguistic units, especially in SLP talk, that are relevant in research and practice. The tool offers a way to automatically measure SLP talk in clinical settings, which will support research seeking to understand how SLP talk influences children\'s language growth.
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  • 文章类型: Systematic Review
    治疗反应是指个体从治疗中受益的程度。本系统综述旨在确定和综合有关预测发育性语言障碍(DLD)儿童语言治疗反应的个体特征的研究证据。
    要有资格加入,文章需要报告一组4-10岁儿童的口头语言治疗计划的结果,并确定DLD,还包括一个或多个治疗前儿童特征与语言治疗结果之间关系的定量分析。七个数据库(护理和相关健康文献累积指数,全球学位论文和论文,教育资源信息中心,语言学与语言行为文摘,PsycINFO,Medline,和WebofScience)在2021年6月和7月进行了文章搜索,并于2023年5月进行了搜索更新。研究按提供的治疗类型进行分类,并对结果进行了定性合成。
    该综述包括31项研究,1,551名DLD参与者,以及超过300项预测因子对语言治疗反应的影响的统计检验。大多数研究(n=21)只包括单语英语,有五项研究,包括双语者和五项包括非英语的单语使用者。语言治疗针对受控或临床条件下的单词学习,在受控或临床条件下的语法学习,或临床条件下的多种语言目标。治疗反应的预测因素总结为四类:认知,人口统计学,预处理语言水平,和其他。
    对语言治疗反应的预测因子的重要测试相对较少。证据的主要局限性在于,大多数纳入研究旨在考虑语言治疗效果,不是治疗反应的预测因子。需要越来越多的研究关注DLD儿童语言治疗反应的预测因素问题,以加强治疗并优化个别儿童的结果。
    https://doi.org/10.23641/asha.26170006。
    UNASSIGNED: Treatment response is the degree to which an individual benefits from a treatment. This systematic review sought to identify and synthesize research evidence regarding individual characteristics that predict language treatment response among children with developmental language disorder (DLD).
    UNASSIGNED: To be eligible for inclusion, articles needed to report results of an oral language treatment program in a group of children aged 4-10 years with identified DLD and also include a quantitative analysis of the relation between one or more pretreatment child characteristics and the outcome of language treatment. Seven databases (Cumulated Index to Nursing and Allied Health Literature, Dissertations and Theses Global, Education Resources Information Center, Linguistics and Language Behavior Abstracts, PsycINFO, Medline, and Web of Science) were searched for articles in June and July 2021, with search updates conducted in May 2023. Studies were categorized by the type of treatment provided, and results were synthesized qualitatively.
    UNASSIGNED: The review included 31 studies, 1,551 participants with DLD, and over 300 statistical tests of a predictor\'s effect on language treatment response. Most studies (n = 21) included only monolingual speakers of English, with five studies including bilinguals and five including monolingual speakers of non-English languages. Language treatments targeted word learning in controlled or clinical conditions, grammatical learning in controlled or clinical conditions, or multiple language targets in clinical conditions. Predictors of treatment response are summarized across four categories: cognitive, demographic, pretreatment language levels, and other.
    UNASSIGNED: There were relatively few significant tests of the predictors of language treatment response. A central limitation of the evidence is that most included studies were designed to consider language treatment efficacy, not predictors of treatment response. Increasing research attention to the question of predictors of language treatment response in children with DLD is needed to enhance treatment and optimize outcomes for individual children.
    UNASSIGNED: https://doi.org/10.23641/asha.26170006.
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  • 文章类型: Journal Article
    目的:评估两种言语和语言治疗方法对帕金森病患者构音障碍的临床疗效。
    方法:务实,基于英国,多中心,三臂,平行组,未失明,随机对照试验。
    方法:在2016年9月26日至2020年3月16日期间,在门诊或家庭环境中进行了言语和语言治疗干预。
    方法:388名帕金森病和构音障碍患者。
    方法:参与者被随机分配到三组中的一组(1:1:1):130接受LeeSilverman语音治疗(LSVTLOUD),129到NHS言语和语言治疗,和129没有言语和语言治疗。LSVTLOUD由四个人组成,面对面或远程,每周50分钟的会议在四周内交付。基于家庭的实践活动在治疗日设置为每天5-10分钟,在非治疗日设置为每天两次15分钟。NHS言语和语言治疗的剂量由当地治疗师根据参与者的需求确定(根据先前的研究估计,NHS言语和语言治疗参与者将在六到八周内每周平均接受一次会议)。接受了NHS言语和语言治疗的当地做法,除了LSVTLOUD协议中的那些。分析基于意向治疗原则。
    方法:主要结果是三个月自我报告的嗓音障碍指数的总分。
    结果:接受LSVTLOUD的患者在随机化后3个月的嗓音障碍指数得分低于未接受言语和语言治疗的患者(-8.0分(99%置信区间-13.3至-2.6);P<0.001)。没有证据表明NHS言语和语言治疗与无言语和语言治疗之间的语音障碍指数得分存在差异(1.7分(-3.8至7.1);P=0.43)。LSVTLOUD组患者的嗓音障碍指数得分也低于随机接受NHS言语和语言治疗的患者(-9.6分(-14.9至-4.4);P<0.001)。LSVTLOUD组报告了93起不良事件(主要是声带拉伤),NHS言语和语言治疗组46人,没有言语和语言治疗组。无严重不良事件记录。
    结论:LSVTLOUD在减少参与者报告的声音问题影响方面比没有言语和语言治疗和NHS言语和语言治疗更有效。与没有言语和语言治疗相比,NHS言语和语言治疗没有任何益处的证据。
    背景:ISRCTN注册表ISRCTN12421382。
    To assess the clinical effectiveness of two speech and language therapy approaches versus no speech and language therapy for dysarthria in people with Parkinson\'s disease.
    Pragmatic, UK based, multicentre, three arm, parallel group, unblinded, randomised controlled trial.
    The speech and language therapy interventions were delivered in outpatient or home settings between 26 September 2016 and 16 March 2020.
    388 people with Parkinson\'s disease and dysarthria.
    Participants were randomly assigned to one of three groups (1:1:1): 130 to Lee Silverman voice treatment (LSVT LOUD), 129 to NHS speech and language therapy, and 129 to no speech and language therapy. LSVT LOUD consisted of four, face-to-face or remote, 50 min sessions each week delivered over four weeks. Home based practice activities were set for up to 5-10 mins daily on treatment days and 15 mins twice daily on non-treatment days. Dosage for the NHS speech and language therapy was determined by the local therapist in response to the participants\' needs (estimated from prior research that NHS speech and language therapy participants would receive an average of one session per week over six to eight weeks). Local practices for NHS speech and language therapy were accepted, except for those within the LSVT LOUD protocol. Analyses were based on the intention to treat principle.
    The primary outcome was total score at three months of self-reported voice handicap index.
    People who received LSVT LOUD reported lower voice handicap index scores at three months after randomisation than those who did not receive speech and language therapy (-8.0 points (99% confidence interval -13.3 to -2.6); P<0.001). No evidence suggests a difference in voice handicap index scores between NHS speech and language therapy and no speech and language therapy (1.7 points (-3.8 to 7.1); P=0.43). Patients in the LSVT LOUD group also reported lower voice handicap index scores than did those randomised to NHS speech and language therapy (-9.6 points (-14.9 to -4.4); P<0.001). 93 adverse events (predominately vocal strain) were reported in the LSVT LOUD group, 46 in the NHS speech and language therapy group, and none in the no speech and language therapy group. No serious adverse events were recorded.
    LSVT LOUD was more effective at reducing the participant reported impact of voice problems than was no speech and language therapy and NHS speech and language therapy. NHS speech and language therapy showed no evidence of benefit compared with no speech and language therapy.
    ISRCTN registry ISRCTN12421382.
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  • 文章类型: Journal Article
    The S3 Guideline on the Treatment of Language Development Disorders: Summary of Recommendations Abstract: The German S3 Guidelines on the Treatment of Developmental Speech and Language Disorders (AWMF: No. 049-015) were published on the AWMF homepage at the end of 2022. The German Society for Phoniatrics and Paedaudiologie coordinated the work and developed the guideline text together with linguists and speech and language therapists. Many scientific medical societies consented to the respective recommendations. For the first time in the German-speaking area, the guideline group reviewed international research results on the treatment of various speech and language disorders and formulated evidence- or consensus-based recommendations for clinical care. The present article summarizes these recommendations and evaluates the guidelines from the perspective of child and adolescent psychiatry and psychotherapy.
    Zusammenfassung: Die S3-Leitlinie zur Therapie von Sprachentwicklungsstörungen (AWMF: Nr. 049-015), die Ende 2022 auf der Homepage der AWMF veröffentlich wurde, ist unter Federführung der Deutschen Gesellschaft für Phoniatrie und Pädaudiologie in Kooperation mit zahlreichen Sprachwissenschaftler_innen und Sprachtherapeut_innen entwickelt und von zahlreichen wissenschaftlichen medizinischen Fachgesellschaften konsentiert worden. Die Leitliniengruppe hat erstmalig für den deutschen Sprachraum versucht, die internationale Studienlage zur Therapie unterschiedlicher Sprach- und Sprechstörungen aufzuarbeiten und darauf basierend Evidenz- oder auch Konsensus-basierte Empfehlungen für die klinische Versorgung zu formulieren. In dem vorliegenden Artikel werden diese Empfehlungen zusammenfassend dargestellt, und es wird eine Wertung der Leitlinie aus Kinder- und Jugendpsychiatrischer Sicht vorgenommen.
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  • 文章类型: Journal Article
    我们调查了StoryChamps对患有发育性语言障碍(DLD)的三年级西班牙语-英语双语儿童的口语效果。
    我们实施了并发的多基线跨参与者单例设计,其中有四个具有DLD的西班牙语-英语双语三年级学生。治疗在12个疗程中进行,每周约2个疗程。在干预后1、2和4周进行维持治疗。参与者被明确地教授故事语法元素,因果关系和时间联系,以及故事复述和个人叙述中的修饰语。因变量是故事语法,语法复杂性,故事复述中的修饰语和听力理解,以及个人叙述中的故事语法和语法复杂性。在每个基线结束时评估结果指标,干预,和维护会话使用叙事语言措施-听力(NLM-L)。
    结果测量的视觉分析表明,干预期间NLM-L得分略有增加,并伴有明显的变异性。对故事复述表现的案例分析表明,对两名参与者的故事语法以及对一名参与者的语法复杂性和修饰语使用具有干预作用。对于个人叙述,个人叙事表现的案例内部分析表明,对一名参与者的故事语法有干预作用。
    总的来说,StoryChamps展示了在四分之三的参与者中改善故事重述中故事语法使用的功效。它没有显示出改善语法复杂性的功效,修饰符使用,或者故事中的听力理解,它也没有显示出改善个人叙述中的故事语法和语法复杂性的功效。
    https://doi.org/10.23641/asha.26053033。
    UNASSIGNED: We investigated the efficacy of Story Champs for improving oral language in third-grade Spanish-English bilingual children with developmental language disorder (DLD).
    UNASSIGNED: We implemented a concurrent multiple-baseline across-participants single-case design with four bilingual Spanish-English third-grade students with DLD. Treatment was carried out over 12 sessions with approximately two sessions per week. Maintenance sessions were conducted 1, 2, and 4 weeks postintervention. Participants were explicitly taught story grammar elements, causal and temporal connections, and modifiers within story retells and personal narratives. Dependent variables were story grammar, grammatical complexity, modifiers and listening comprehension within story retells, and story grammar and grammatical complexity within personal narratives. Outcome measures were assessed at the end of every baseline, intervention, and maintenance session using the Narrative Language Measures-Listening (NLM-L).
    UNASSIGNED: Visual analyses for outcome measures suggested slight increases in scores on the NLM-L during intervention accompanied by marked variability. Within-case analyses of story retell performance suggested an intervention effect on story grammar for two participants and on grammatical complexity and modifier use for one participant. For personal narratives, within-case analyses of personal narrative performance suggested an intervention effect on story grammar for one participant.
    UNASSIGNED: Overall, Story Champs demonstrated efficacy for improving story grammar use in story retells for three out of four participants. It did not show efficacy for improving grammatical complexity, modifier use, or listening comprehension within story retells, nor did it show efficacy for improving story grammar and grammatical complexity within personal narratives.
    UNASSIGNED: https://doi.org/10.23641/asha.26053033.
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  • 文章类型: Journal Article
    我们研究了使用以不同剂量递送的SHAPECODING™系统的高度个性化的形态句法干预的有效性。
    8名年龄为8岁的发育性语言障碍儿童;0-10岁;10岁(岁;月)接受了10小时的明确个性化干预,以30分钟的单独疗程进行,每周一次,持续20周。在至少四次基线探针测试之后,每个会话的两个语法目标收到明确的指令,直到它们达到标准(90%),当引入下一个目标时。要控制会话长度和教学片段密度,要么两个目标每节接受20个教学集,要么一个目标接受10个教学集,另一个目标接受30个教学集。还对已完成的目标进行了维护测试。
    干预后的探针测试得分明显高于基线阶段(d=1.6),在基线或维持阶段没有变化。然而,干预阶段的进展非常显著.一名参与者在干预方面表现出明显更快的进展,而一个(注意力得分最低)进展甚微。在考虑相对于累积干预会议的进展时,每节教学30次,进度更快,10次较慢。然而,当累积教学事件被用作预测因子时,所有三个疗程内剂量都显示出非常相似的进展速度,每集教学的正确反应几率增加3.9%。达到的目标平均需要40-60个教学集。
    除一名参与者外,个性化干预是非常有效和高效的。因此,个性化目标识别过程和干预方法值得在更大的儿童群体中进一步研究。跨课程提供的每个目标的累计教学次数似乎是关键。因此,临床医生应该瞄准高教学发作率,特别是如果会话的数量受到限制。否则,干预调度可以是灵活的。
    https://doi.org/10.23641/asha.25996168。
    UNASSIGNED: We investigated the effectiveness of a highly individualized morphosyntactic intervention using the SHAPE CODING™ system delivered at different dosages.
    UNASSIGNED: Eight children with developmental language disorder aged 8;0-10;10 (years;months) received 10 hr of explicit individualized intervention for morphosyntax delivered in 30-min individual sessions once per week for 20 weeks. Following at least four baseline probe tests, two grammatical targets per session received explicit instruction until they reached criterion (90%), when the next target was introduced. To control for session length and teaching episode density, either both targets received 20 teaching episodes per session or one target received 10 teaching episodes and the other 30. Maintenance testing of completed targets was also carried out.
    UNASSIGNED: Scores on probe tests post-intervention were significantly higher than during the baseline phase (d = 1.6) with no change during the baseline or maintenance phases. However, progress during the intervention phase was highly significant. One participant showed significantly faster progress with intervention, while one (with the lowest attention score) made little progress. When considering progress relative to cumulative intervention sessions, progress was faster with 30 teaching episodes per session and slower with 10. However, when cumulative teaching episodes were used as the predictor, all three within-session dosages showed very similar rates of progress, with the odds of a correct response increasing by 3.9% for each teaching episode. The targets that were achieved required an average of 40-60 teaching episodes.
    UNASSIGNED: With the exception of one participant, the individualized intervention was highly effective and efficient. Thus, the individualized target identification process and intervention method merit further research in a larger group of children. The cumulative number of teaching episodes per target provided across sessions appeared to be key. Thus, clinicians should aim for high teaching episode rates, particularly if the number of sessions is constrained. Otherwise, intervention scheduling can be flexible.
    UNASSIGNED: https://doi.org/10.23641/asha.25996168.
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  • 文章类型: Journal Article
    背景:患有失语症的卒中幸存者希望改善他们的日常谈话(话语)。在目前的英国实践中,90%的言语和语言治疗师认为话语评估和治疗是他们角色的一部分,但受到资源障碍的阻碍。时间和专业知识。临床上需要明确的话语评估和治疗。LUNA是一种针对单词的多层次治疗方法,解决这一临床需求的个人故事中的句子和话语宏观结构。
    目的:本研究旨在评估随机候补名单对照试验中LUNA试验程序的可行性和可接受性,并评估初步疗效。
    方法:本文报告了第二阶段,等候名单控制,概念验证可行性试验。从社区招募慢性失语症参与者(n=28),并随机分为即时(n=14)或延迟(n=14)组。通过视频会议技术每周两次进行LUNA治疗,为期10周,缩放。在招募和保留参与者方面评估了可行性,坚持,缺少数据,和治疗保真度。根据与话语相关的结果测量的组间差异评估初步治疗效果。语言,和社会心理状态。
    结果:远程LUNA试验是可行的:85%符合条件的人同意该试验;试验保留率为86%;87%的治疗疗程如期完成,79%的参与者完成了80%以上的治疗方案;仅退出参与者的数据缺失;治疗保真度高,依从性为92%;只有一项临床结局指标显示天花板效应.临床结局指标的ANCOVA分析显示,具有中等和较大效应大小的组差异,指示,改进单词的产生,句子,话语宏观结构,整体语言功能(WAB-R),和LUNA治疗后的社会心理状态(VAMS)。对于大多数测量的结果,类似的治疗益处被认为是次要的,非参数分析。
    结论:这些发现支持对LUNA的临床疗效和成本效益进行大规模评估。
    背景:临床试验注册:NCT05847023(clinicaltrials.gov)。
    BACKGROUND: Stroke survivors with aphasia want to improve their everyday talking (discourse). In current UK practice, 90% of speech and language therapists believe discourse assessment and treatment is part of their role but are hampered by barriers in resources, time and expertise. There is a clinical need for well-articulated discourse assessment and treatments. LUNA is a multi-level treatment targeting words, sentences and discourse macrostructure in personal stories that addresses this clinical need.
    OBJECTIVE: This study aimed to assess the feasibility and acceptability of LUNA trial procedures in a randomised waitlist-controlled trial; and to evaluate preliminary efficacy.
    METHODS: This paper reports a phase II, waitlist-controlled, proof-of-concept feasibility trial. Participants with chronic aphasia (n = 28) were recruited from the community and randomised to an Immediate (n = 14) or Delayed (n = 14) group. LUNA treatment was delivered twice weekly for 10 weeks via the videoconferencing technology, Zoom. Feasibility was assessed in terms of participant recruitment and retention, adherence, missing data, and treatment fidelity. Preliminary treatment efficacy was assessed in terms of between group differences in outcome measures relating to discourse, language, and psychosocial state.
    RESULTS: The remote LUNA trial was feasible: 85% of those eligible consented to the trial; trial retention was 86%; 87% of treatment sessions were delivered as scheduled, and 79% of participants completed 80%+ of the treatment programme; data was missing only for participants who withdrew; treatment fidelity was high at 92% adherence; and only one clinical outcome measure demonstrated ceiling effects. ANCOVA analysis of the clinical outcome measures revealed group differences with medium and large effect sizes, indicating, improvements in the production of words, sentences, discourse macrostructure, overall language functioning (WAB-R), and psychosocial state (VAMS) following LUNA treatment. For most outcomes measured, similar treatment benefits were suggested in a secondary, non-parametric analysis.
    CONCLUSIONS: Large-scale evaluation of the clinical efficacy and cost-effectiveness of LUNA is warranted and supported by these findings.
    BACKGROUND: Clinical trials registration: NCT05847023 (clinical trials.gov).
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  • 文章类型: Journal Article
    非侵入性脑刺激已被广泛用作中风后失语症的辅助治疗。
    本研究的目的是研究非侵入性脑刺激作为辅助治疗对中风后失语症命名功能的影响。
    本综述包括涉及5个数据库的随机对照试验(RCT)(WebofScience,Embase,科克伦图书馆,OVID和PubMed)研究了电刺激对中风患者的影响。搜索包括截至2023年11月出版的文献。
    我们确定了18项研究,标准化平均差异(SMD)表明TMS和tDCS的影响大小为小到中等。此外,治疗效果随着时间的推移而持续,表明长期疗效。
    本研究提示NIBS联合言语和语言治疗可有效促进卒中后失语症(PSA)患者命名功能的恢复,且效果持久。
    UNASSIGNED: Non-invasive brain stimulation has been widely used as an adjunctive treatment for aphasia following stroke.
    UNASSIGNED: The aim of this study was to investigate the effect of non-invasive brain stimulation as an adjunctive treatment on naming function in aphasia following stroke.
    UNASSIGNED: This review included randomized controlled trials (RCTs) involving 5 databases (Web of Science, Embase, Cochrane Library, OVID and PubMed) that investigated the effects of electrical stimulation on stroke patients. The search included literature published up to November 2023.
    UNASSIGNED: We identified 18 studies, and the standardized mean differences (SMDs) showed that the effect sizes of TMS and tDCS were small to medium. Moreover, the treatment effects persisted over time, indicating long-term efficacy.
    UNASSIGNED: This study suggested that NIBS combined with speech and language therapy can effectively promote the recovery of naming function in patients with post-stroke aphasia (PSA) and that the effects are long lasting.
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