海洛因使用和处方阿片类药物滥用(POM)与外化和内化特征的关联模式有所不同。本研究检查了海洛因使用和POM是否显示出与行为障碍(CD)症状的不同病因重叠,成人反社会行为(AAB),和重度抑郁发作(MDE),如何将海洛因的使用和POM聚集成单一表型可能会产生偏差,探索潜在的性别差异。来自澳大利亚双胞胎登记处的七千一百六十四个双胞胎(ATR;59.81%的女性;Mage=30.58岁)报告了终生使用海洛因,POM,CD症状,AAB,以及半结构化访谈中的MDE症状。生物识别模型将表型方差和协方差分解为加性遗传,常见的环境,和独特的环境影响。海洛因使用差异的比例可归因于与CD共有的因素,AAB,MDE,分别,是41%,41%,男性为0%,26%,19%,女性占42%;POM,比例为33%,35%,男性20%和15%,9%,女性占13%。CD和AAB与女性使用海洛因和男性使用POM的遗传相关性更强。在男性中,MDE与POM的遗传相关性高于与海洛因的使用,但在女性中,与海洛因的使用比POM的基因相关性更强。使用总阿片类药物(MIS)使用变量的分析偏向于POM,这是更普遍的表型。病因影响的程度和来源可能因阿片类药物(误用)的形式和性别而异。可能需要在未来的阿片类药物研究中对海洛因的使用和POM进行汇总。(PsycInfo数据库记录(c)2024APA,保留所有权利)。
Patterns of association with externalizing and internalizing features differ across heroin use and prescription opioid misuse (POM). The present study examined whether heroin use and POM display differential etiologic overlap with symptoms of conduct disorder (CD), adult antisocial behavior (AAB), and major depressive episodes (MDEs), how aggregating heroin use and POM into a single phenotype may bias results, and explored potential sex differences. Seven thousand one hundred and sixty-four individual twins from the Australian Twin Registry (ATR; 59.81% female; Mage = 30.58 years) reported lifetime heroin use, POM, CD symptoms, AABs, and MDE symptoms within a semi-structured interview. Biometric models decomposed phenotypic variance and covariance into additive genetic, common environmental, and unique environmental effects. The proportion of variance in heroin use attributable to factors shared with CD, AAB, and MDE, respectively, was 41%, 41%, and 0% for men and 26%, 19%, and 42% for women; for POM, the proportions were 33%, 35%, and 20% for men and 15%, 9%, and 13% for women. CD and AAB were more strongly genetically correlated with heroin use among women and with POM among men. MDE was more strongly genetically correlated with POM than with heroin use among men, but more strongly genetically correlated with heroin use than with POM among women. Analyses using an aggregate opioid (mis)use variable were biased toward POM, which was the more prevalent phenotype. Magnitude and source of etiologic influence may differ across forms of opioid (mis)use and sex. Disaggregating heroin use and POM in future opioid research may be warranted. (PsycInfo Database Record (c) 2024 APA, all rights reserved).