每天肌内给药 4 周后 , 双氯芬酸钠盐在尤卡坦小型猪 ( Sus scrofa ) 中的毒性。
关键词: 4-Week repeated toxicity AAALAC, association for assessment and accreditation of laboratory animal care ALT, alanine aminotransferase AP, Alkaline phosphatase AST, aspartate aminotransferase AUC, area under the concentration-time curve BUN, blood urea nitrogen BW, body weight CAS, chemical abstracts service CL, clearance COX, cyclooxygenase CREA, creatine CRO, contract research organization CV, coefficients of variation Cmax, maximum plasma concentration DSS, diclofenac sodium salt Diclofenac sodium salt ECG, Electrocardiogram GI, gastrointestinal GLP, good laboratory practice H&E, hematoxylin and eosin HED, human effective dose HR, heart rate IACUC, institutional animal care and use committee Minipig NDA, new drug application NOAEL, No-observed-adverse-effect levels NSAIDs, nonsteroidal anti-inflammatory drugs No-observed-adverse-effect level RBC, red blood cell SD, standard deviation TK, toxicokinetics TP, total protein Tmax, time to maximum plasma concentration WBC, white blood cell aVF, augmented vector foot aVL, augmented vector left aVR, augmented vector right
来 源:
DOI:10.1016/j.toxrep.2021.02.022
PDF(Sci-hub)
PDF(Pubmed)