背景近年来,各个科学部门都取得了重大进展,特别是在医疗保健和药物研究方面。这一进展是由增强型传感材料和方法的发展推动的。电化学传感由于其高灵敏度,已成为检测和分析药物分子的重要工具,特异性,和快速的响应时间。在各种药物中,扑热息痛,也被称为对乙酰氨基酚,因其镇痛和解热特性而被广泛使用。扑热息痛的准确检测是至关重要的,因为它的广泛使用和潜在的过量,会导致严重的肝损伤.钼酸铜(CuMoO4)是一种过渡金属氧化物,因其优异的导电性和电化学稳定性而备受关注。这些性质使其成为用于电化学传感器的有希望的候选物。CuMoO4作为传感器材料的能力因其独特的结构和形态特征而增强,可以在合成过程中定制。目的本研究旨在合成CuMoO4,并考察其对药物分子检测的电化学传感能力,特别是扑热息痛。材料和方法使用不涉及任何表面活性剂的沉淀法合成CuMoO4。选择这种方法是为了简化合成过程并避免表面活性剂的潜在污染。使用场发射扫描电子显微镜(FE-SEM)研究了合成的CuMoO4纳米颗粒的形态。能量色散X射线光谱(EDX)证实了CuMoO4纳米材料的纯度。使用X射线衍射(XRD)进行结构分析。为了评估CuMoO4对扑热息痛的电化学传感能力,采用差分脉冲伏安法(DPV)。DPV是一种灵敏的电化学技术,可以检测与分析物的存在相对应的电流响应变化。结果合成的CuMoO4呈岩石状结构,如FE-SEM成像所示。由于可用于与分析物相互作用的表面积增加,这种形态对于电化学应用是有利的。EDX证实了CuMoO4纳米材料的纯度,没有明显的杂质。XRD分析表明,CuMoO4纳米粒子在性质上是结晶的,这有利于一致和可再现的电化学行为。DPV分析表明,随着扑热息痛浓度的增加,CuMoO4传感器的电流响应呈线性增加。这种线性关系表明CuMoO能够有效地检测扑热息痛,具有强大且可量化的信号响应。结论使用简单的沉淀法成功合成了CuMoO4纳米材料,并具有岩石状形貌和晶体结构。使用DPV的电化学测试表明,CuMoO4具有优异的检测对乙酰氨基酚的传感能力,具有清晰和线性的电流响应。这些发现表明,CuMoO4是一种有前途的电化学传感材料,用于药物检测,可能提供一种可靠和有效的方法来监测扑热息痛和可能的其他药物在各种设置。
Background In recent years, significant advancements have been made in various scientific sectors, particularly in healthcare and pharmaceutical research. This progress has been driven by the development of enhanced sensing materials and methodologies. Electrochemical sensing has become an important tool in detecting and analyzing drug molecules due to its high sensitivity, specificity, and rapid response times. Among various drugs, paracetamol, also known as acetaminophen, is widely used for its analgesic and antipyretic properties. Accurate detection of paracetamol is crucial due to its widespread use and potential for overdose, which can lead to severe liver damage. Copper molybdate (CuMoO4) is a transition metal oxide that has garnered attention for its excellent electrical conductivity and electrochemical stability. These properties make it a promising candidate for use in electrochemical sensors. The ability of CuMoO4 to act as a sensor material is enhanced by its unique structural and morphological characteristics, which can be tailored during synthesis. Aim This study aimed to synthesize CuMoO4 and investigate its electrochemical sensing capability for the detection of drug molecules, specifically paracetamol. Materials and method CuMoO4 was synthesized using a precipitation method that did not involve any surfactants. This approach was chosen to simplify the synthesis process and avoid potential contamination from surfactants. The morphology of the synthesized CuMoO4 nanoparticles was investigated using a field emission scanning electron microscope (FE-SEM). Energy-dispersive X-ray spectroscopy (EDX) confirmed the purity of the CuMoO4 nanomaterial. Structural analysis was performed using X-ray diffraction (XRD). To evaluate the electrochemical sensing capability of CuMoO4 for paracetamol, Differential pulse voltammetry (DPV) was employed. DPV is a sensitive electrochemical technique that can detect changes in current response corresponding to the presence of analytes. Results The synthesized CuMoO4 exhibited a rock-like structure, as revealed by FE-SEM imaging. This morphology is advantageous for electrochemical applications due to the increased surface area available for interaction with analytes. EDX confirmed the purity of the CuMoO4 nanomaterial, showing no significant impurities. XRD analysis indicated that the CuMoO4 nanoparticles were crystalline in nature, which is beneficial for consistent and reproducible electrochemical behavior. The DPV analysis demonstrated that the CuMoO4 sensor exhibited a linear increase in current response with increasing concentrations of paracetamol. This linear relationship indicates that CuMoO₄ is capable of detecting paracetamol effectively, with a strong and quantifiable signal response. Conclusion The CuMoO4 nanomaterial was successfully synthesized using a simple precipitation method and was characterized by its rock-like morphology and crystalline structure. Electrochemical testing using DPV showed that CuMoO4 has excellent sensing capabilities for detecting paracetamol, with a clear and linear current response. These findings suggest that CuMoO4 is a promising electrochemical sensing material for drug detection, potentially offering a reliable and efficient method for monitoring paracetamol and possibly other pharmaceuticals in various settings.