传统的韩国均衡饮食(K饮食)可以改善能量,葡萄糖,和脂质代谢。为了评估这一点,我们进行了一项随机交叉临床试验,涉及30-40岁的参与者,他们被随机分配到两组-K饮食或西化的韩国控制饮食,估计能量需求(EER)为1900千卡。经过4周的冲洗期,他们改变了饮食,并遵循了4周。碳水化合物,蛋白质,基于能量摄入的脂肪比例接近K饮食(65:15:20)和对照饮食(60:15:25)的目标值。对照饮食和K饮食的血糖指数分别为50.3±3.6和68.1±2.9,控制饮食和K饮食中的每日胆固醇含量分别为280和150毫克,分别。涉及能量的人体测量和生化参数,葡萄糖,在4周干预前后,使用UPLC-QTOF-MS测定血浆代谢产物和脂质代谢。经过四周的干预,两种饮食都改善了人体测量和生化变量,但是与对照饮食相比,K饮食显着减少了它们。血清总胆固醇,非高密度脂蛋白胆固醇,与对照组相比,K饮食组的甘油三酸酯浓度显着降低。腰围(p=0.108)和胰岛素抵抗指数(QUICKI,p=0.089)在K饮食组中倾向于低于对照饮食组。血浆代谢物表明,与对照饮食组相比,K饮食组的参与者倾向于降低胰岛素抵抗。氨基酸,尤其是支链氨基酸,酪氨酸,色氨酸,和谷氨酸,K-饮食组的L-同型半胱氨酸浓度明显低于对照饮食组(p<0.05)。血浆谷胱甘肽浓度,抗氧化剂状态的指标,和3-羟基丁酸浓度,K饮食组高于对照饮食组。总之,具有足够卡路里以满足EER的K-饮食通过减少肥胖女性循环中与胰岛素抵抗相关的氨基酸和增加酮来缓解血脂异常。
A traditional balanced Korean diet (K-diet) may improve energy, glucose, and lipid metabolism. To evaluate this, we conducted a randomized crossover clinical trial, involving participants aged 30-40 years, who were randomly assigned to two groups-a K-diet or westernized Korean control diet daily, with an estimated energy requirement (EER) of 1900 kcal. After a 4-week washout period, they switched the diet and followed it for 4 weeks. The carbohydrate, protein, and fat ratios based on energy intake were close to the target values for the K-diet (65:15:20) and control diet (60:15:25). The glycemic index of the control diet and the K-diet was 50.3 ± 3.6 and 68.1 ± 2.9, respectively, and daily cholesterol contents in the control diet and K-diet were 280 and 150 mg, respectively. Anthropometric and biochemical parameters involved in energy, glucose, and lipid metabolism were measured while plasma metabolites were determined using UPLC-QTOF-MS before and after the 4-week intervention. After the four-week intervention, both diets improved anthropometric and biochemical variables, but the K-diet significantly reduced them compared to the control diet. Serum total cholesterol, non-high-density lipoprotein cholesterol, and triglyceride concentrations were significantly lower in the K-diet group than in the control diet group. The waist circumference (p = 0.108) and insulin resistance index (QUICKI, p = 0.089) tended to be lower in the K-diet group than in the control diet group. Plasma metabolites indicated that participants in the K-diet group tended to reduce insulin resistance compared to those in the control diet group. Amino acids, especially branched-chain amino acids, tyrosine, tryptophan, and glutamate, and L-homocysteine concentrations were considerably lower in the K-diet group than in the control diet group (p < 0.05). Plasma glutathione concentrations, an index of antioxidant status, and 3-hydroxybutyric acid concentrations, were higher in the K-diet group than in the control diet group. In conclusion, a K-diet with adequate calories to meet EER alleviated dyslipidemia by decreasing insulin resistance-related amino acids and increasing ketones in the circulation of obese women.