Abstract：
Objective. Adiponectin is an internally produced bioactive compound with a protective role against the insulin resistance-related diseases. Finding an adiponectin modifier can play a beneficial role in preventing the progression of the diseases, particularly in the prediabetic patients, as a high-risk population. This study was undertaken to examine the effect of dietary sorghum grain for a week on the plasma adiponectin levels in prediabetic patients. Methods. The study involved 26 (13+13) participants in both control and intervention groups. The control group maintained their habitual diet of white rice, while the intervention group replaced their habitual diet of white rice with sorghum grain for seven consecutive days. In all participants, the adiponectin concentration was measured before and after the intervention period. Results. Most study subjects had central obesity and dyslipidemia. Adiponectin levels after the intervention period decreased from the baseline in the control and sorghum groups including in all BMI groups. The change of decreasing adiponectin level was greater in the control than the sorghum group and in line with greater BMI in the sorghum group, but statistically insignificant. No significant difference in adiponectin concentrations was found among BMI groups. Conclusion. Sorghum grain consumption for a week is insufficient to increase adiponectin levels in the prediabetic patients. Insulin resistance, central obesity, and dyslipidemia may be the confounding variables that alter the favorable effect of sorghum on adiponectin. Longer sorghum consumption or other interventions may be needed to increase the adiponectin levels in people under these conditions.
摘要：
Objective.脂联素是一种内部产生的生物活性化合物，对胰岛素抵抗相关疾病具有保护作用。找到脂联素修饰剂可以在预防疾病进展方面发挥有益作用，特别是在糖尿病前期患者中，作为高危人群。进行这项研究是为了检查一周的高粱谷物对糖尿病前期患者血浆脂联素水平的影响。方法。该研究涉及26名（13+13）参与者，包括对照组和干预组。对照组保持了白米的习惯性饮食,而干预组连续七天用高粱谷物代替习惯性的白米饮食。在所有参与者中,在干预前后测定脂联素浓度.结果。大多数研究对象患有中心性肥胖和血脂异常。干预期后，对照组和高粱组（包括所有BMI组）的脂联素水平从基线下降。对照组脂联素水平下降的变化大于高粱组，高粱组BMI较大，但统计上微不足道。BMI组之间的脂联素浓度没有显着差异。结论。高粱谷物消费一周不足以增加糖尿病前期患者的脂联素水平。胰岛素抵抗,中心性肥胖,和血脂异常可能是改变高粱对脂联素有利作用的混杂变量。在这些条件下，可能需要更长的高粱消费或其他干预措施来增加人们的脂联素水平。
