自1990年代初以来,当罗伯特和萨博的细胞保护概念已经超过十年的时候,但仍未在治疗中实施,我们建议稳定的胃十五肽BPC157是细胞保护概念中最相关的介质。因此,它可以翻译胃和胃肠粘膜的维护,上皮,和内皮细胞保护其他组织愈合的治疗(有机保护),容易适用,在人胃液中天然且稳定超过24小时。这些压倒了目前的临床证据(即,溃疡性结肠炎,第二阶段,没有副作用,并且在毒理学研究中没有致死剂量(LD1)),作为BPC157治疗有效结合各种组织愈合和病变抵消。BPC157细胞保护相关性和血管恢复,抵押品途径的激活,膜稳定剂,眼部治疗,伤口愈合能力,大脑-肠道和肠道-大脑功能,肿瘤恶病质抵消,肌肉,肌腱,韧带,和骨骼紊乱的抵消,还有心脏病,心肌梗塞,心力衰竭,肺动脉高压,心律失常,和血栓形成的对抗作用出现在最近的综述中。这里,作为概念分辨率,我们通过激活附带救助途径来回顾对先进的Virchow三合会情况的反作用,根据受伤情况,激活的奇静脉直接血流输送,从酒精胃部病变开始,以抵消闭塞/闭塞样综合征。对抗主要血管衰竭(充血的下腔静脉和肠系膜上静脉,崩溃的奇静脉,腹主动脉塌陷)包括大脑的反作用(脑内和脑室内出血),心脏(充血,严重的心律失常),肺(出血),肝脏的淤血和病变,肾,和胃肠道,颅内(上矢状窦),门脉和腔静脉高血压,主动脉低血压,和血栓形成,外围和中央。
Since the early 1990s, when Robert\'s and Szabo\'s
cytoprotection concept had already been more than one decade old, but still not implemented in therapy, we suggest the stable gastric pentadecapeptide BPC 157 as the most relevant mediator of the
cytoprotection concept. Consequently, it can translate stomach and gastrointestinal mucosal maintenance, epithelium, and endothelium cell protection to the therapy of other tissue healing (organoprotection), easily applicable, as native and stable in human gastric juice for more than 24 h. These overwhelm current clinical evidence (i.e., ulcerative colitis, phase II, no side effects, and no lethal dose (LD1) in toxicology studies), as BPC 157 therapy effectively combined various tissue healing and lesions counteraction. BPC 157
cytoprotection relevance and vascular recovery, activation of collateral pathways, membrane stabilizer, eye therapy, wound healing capability, brain-gut and gut-brain functioning, tumor cachexia counteraction, muscle, tendon, ligament, and bone disturbances counteraction, and the heart disturbances, myocardial infarction, heart failure, pulmonary hypertension, arrhythmias, and thrombosis counteraction appeared in the recent reviews. Here, as concept resolution, we review the counteraction of advanced Virchow triad circumstances by activation of the collateral rescuing pathways, depending on injury, activated azygos vein direct blood flow delivery, to counteract occlusion/occlusion-like syndromes starting with the context of alcohol-stomach lesions. Counteraction of major vessel failure (congested inferior caval vein and superior mesenteric vein, collapsed azygos vein, collapsed abdominal aorta) includes counteraction of the brain (intracerebral and intraventricular hemorrhage), heart (congestion, severe arrhythmias), lung (hemorrhage), and congestion and lesions in the liver, kidney, and gastrointestinal tract, intracranial (superior sagittal sinus), portal and caval hypertension, aortal hypotension, and thrombosis, peripherally and centrally.