%0 Journal Article
%T Evaluation of quercetin as a potential cytoprotector against acetaldehyde using the cultured hepatocyte model with aldehyde dehydrogenase isozyme deficiency.
%A Xu Y
%A Sawamoto T
%A Sun R
%A Ishikura A
%A Munemasa S
%A Murata Y
%A Satoh A
%A Matsumoto A
%A Nakamura T
%A Nakamura Y
%J Biosci Biotechnol Biochem
%V 0
%N 0
%D 2024 Jul 11
%M 38991992
%F 2.337
%R 10.1093/bbb/zbae100
%X Protective effect of quercetin against acetaldehyde was evaluated using the cultured hepatocyte models with aldehyde dehydrogenase (ALDH) isozyme deficiency (aldh2-kd and aldh1a1-kd). The quercetin-induced cytoprotection against acetaldehyde in the ALDH1A1-deficient mutant (aldh1a1-kd) was weaker than that in wild type. Furthermore, quercetin did not enhance the ALDH activity in aldh1a1-kd cells, suggesting that ALDH1A1 is involved in the quercetin-induced cytoprotection.