{Reference Type}: Journal Article
{Title}: Evaluation of quercetin as a potential cytoprotector against acetaldehyde using the cultured hepatocyte model with aldehyde dehydrogenase isozyme deficiency.
{Author}: Xu Y;Sawamoto T;Sun R;Ishikura A;Munemasa S;Murata Y;Satoh A;Matsumoto A;Nakamura T;Nakamura Y;
{Journal}: Biosci Biotechnol Biochem
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jul 11
{Factor}: 2.337
{DOI}: 10.1093/bbb/zbae100
{Abstract}: Protective effect of quercetin against acetaldehyde was evaluated using the cultured hepatocyte models with aldehyde dehydrogenase (ALDH) isozyme deficiency (aldh2-kd and aldh1a1-kd). The quercetin-induced cytoprotection against acetaldehyde in the ALDH1A1-deficient mutant (aldh1a1-kd) was weaker than that in wild type. Furthermore, quercetin did not enhance the ALDH activity in aldh1a1-kd cells, suggesting that ALDH1A1 is involved in the quercetin-induced cytoprotection.