Abstract：
Protective effect of quercetin against acetaldehyde was evaluated using the cultured hepatocyte models with aldehyde dehydrogenase (ALDH) isozyme deficiency (aldh2-kd and aldh1a1-kd). The quercetin-induced cytoprotection against acetaldehyde in the ALDH1A1-deficient mutant (aldh1a1-kd) was weaker than that in wild type. Furthermore, quercetin did not enhance the ALDH activity in aldh1a1-kd cells, suggesting that ALDH1A1 is involved in the quercetin-induced cytoprotection.
摘要：
使用醛脱氢酶（ALDH）同工酶缺乏（aldh2-kd和aldh1a1-kd）的培养肝细胞模型评估槲皮素对乙醛的保护作用。在ALDH1A1缺陷型突变体（aldh1a1-kd）中，槲皮素诱导的对乙醛的细胞保护作用弱于野生型。此外，槲皮素不能增强aldh1a1-kd细胞的ALDH活性，表明ALDH1A1参与槲皮素诱导的细胞保护。
