背景:HIV感染的高流行率及其造成的死亡是全世界医疗保健系统面临的挑战之一。在这项研究中,我们分析了艾滋病毒感染者和合并感染患者的生存率,及相关因素。
方法:这项回顾性队列研究是对伊玛目霍梅尼行为疾病咨询中心收治的3030名HIV感染者进行的,德黑兰,伊朗,2004-2018年。所需数据是从个人文件中获得的。使用KaplanMeier图和Log-rank检验来评估不同因素与生存之间的关系。此外,进行Cox回归分析以确定HIV死亡率的有效因素。数据采用STATA软件进行分析,版本14。
结果:研究人群的平均年龄为43.2±9.5[岁],男性占77.3%。在主题中,3.2%的人感染了乙型肝炎,31.5%与丙型肝炎,13.9%患有肺结核(TB)。一,五,十,15年生存率为97.0%,93.0%,86.0%,54.0%,分别。平均生存时间为154.2±0.9个月。年龄超过35岁有入狱史,不安全的性行为,TB,和丙型肝炎与HIV感染者的死亡独立相关(p<0.05)。
结论:与以前的研究相比,本研究中HIV感染者的生存率处于有利的范围。然而,在这项研究中,丙型肝炎合并感染与受试者的生存率降低有关。因此,建议检测并预防和控制HCV共感染,以增加受试者的生存率。
BACKGROUND: The high prevalence of HIV infection and the deaths caused by it is one of the challenges for the healthcare systems throughout the world. In this study, we analyzed the survival of people living with HIV and co-infections, and related factors.
METHODS: This retrospective cohort study was performed on 3030 people living with HIV admitted to Imam Khomeini Behavioral Disease Counseling Center, Tehran, Iran, during 2004-2018. Required data were obtained from the individuals\' files. Kaplan Meier diagrams and Log-rank tests were used to assess the relationship between different factors and survival. In addition, Cox regression analysis was performed to determine the effective factors in HIV mortality. Data were analyzed using STATA software, version 14.
RESULTS: The mean age of studied population was 43.2 ± 9.5 [years] and 77.3 % were male. Among the subjects, 3.2 % were infected with hepatitis B, 31.5 % with hepatitis C, and 13.9 % with Tuberculosis (TB). One, five, ten, and fifteen-year survival rates were 97.0 %, 93.0 %, 86.0 %, and 54.0 %, respectively. The mean survival time was 154.2 ± 0.9 months. Age more than 35, history of imprisonment, Unsafe sexual behavior, TB, and hepatitis C are independently associated with death in people living with HIV (p < 0.05).
CONCLUSIONS: The survival of people living with HIV in the present study was in the favorable range compared to previous studies. However, co-infection with hepatitis C was associated with reduced survival of the subjects in this study. Therefore, it is suggested to detect and then prevent and control HCV co-infection to increase the survival of subjects.