Abstract：
BACKGROUND: Mycoplasma genitalium infection in pregnancy is increasingly reported at similar frequencies to other sexually transmitted infections (STIs). Knowledge on its contribution to adverse pregnancy outcomes is very limited, especially relative to other STIs or bacterial vaginosis (BV). Whether M. genitalium influences birthweight remains unanswered.
METHODS: Associations between birthweight and M. genitalium and other STIs (Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis) and BV in pregnancy were examined in 416 maternal-newborn pairs from a prospective cohort study in Papua New Guinea.
RESULTS: Compared to uninfected women, M. genitalium (-166.9 g, 95% confidence interval [CI]: -324.2 to -9.7 g, p = 0.038) and N. gonorrhoeae (-274.7 g, 95% CI: -561.9 to 12.5 g, p = 0.061) infections were associated with lower birthweight in an adjusted analysis. The association for C. trachomatis was less clear, and T. vaginalis and BV were not associated with lower birthweight. STI prevalence was high for M. genitalium (13.9%), N. gonorrhoeae (5.0%), and C. trachomatis (20.0%); co-infections were frequent. Larger effect sizes on birthweight occurred with co-infections of M. genitalium, N. gonorrhoeae, and/or C. trachomatis.
CONCLUSIONS: M. genitalium is a potential contributor to lower birthweight, and co-infections appear to have a greater negative impact on birthweight. Trials examining the impact of early diagnosis and treatment of M. genitalium and other STIs in pregnancy and preconception are urgently needed.
BACKGROUND: Funding was received from philanthropic grants, the National Health and Medical Research Council, and the Burnet Institute. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
METHODS: Associations between birthweight and M. genitalium and other STIs (Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis) and BV in pregnancy were examined in 416 maternal-newborn pairs from a prospective cohort study in Papua New Guinea.
RESULTS: Compared to uninfected women, M. genitalium (-166.9 g, 95% confidence interval [CI]: -324.2 to -9.7 g, p = 0.038) and N. gonorrhoeae (-274.7 g, 95% CI: -561.9 to 12.5 g, p = 0.061) infections were associated with lower birthweight in an adjusted analysis. The association for C. trachomatis was less clear, and T. vaginalis and BV were not associated with lower birthweight. STI prevalence was high for M. genitalium (13.9%), N. gonorrhoeae (5.0%), and C. trachomatis (20.0%); co-infections were frequent. Larger effect sizes on birthweight occurred with co-infections of M. genitalium, N. gonorrhoeae, and/or C. trachomatis.
CONCLUSIONS: M. genitalium is a potential contributor to lower birthweight, and co-infections appear to have a greater negative impact on birthweight. Trials examining the impact of early diagnosis and treatment of M. genitalium and other STIs in pregnancy and preconception are urgently needed.
BACKGROUND: Funding was received from philanthropic grants, the National Health and Medical Research Council, and the Burnet Institute. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
摘要：
背景：据报道，妊娠期生殖道支原体感染的频率与其他性传播感染（STIs）相似。关于其对不良妊娠结局的贡献的知识非常有限，特别是相对于其他性传播感染或细菌性阴道病（BV）。生殖支原体是否影响出生体重仍未解决。
方法：出生体重与生殖支原体和其他性传播感染（沙眼衣原体，淋病奈瑟菌,和阴道毛滴虫）和BV在巴布亚新几内亚的一项前瞻性队列研究中对416对母体-新生儿对进行了检查。
结果：与未感染的女性相比，生殖支原体（-166.9g，95%置信区间[CI]：-324.2至-9.7g，p=0.038）和淋病奈瑟菌（-274.7g，95%CI：-561.9至12.5g，p=0.061）在调整后的分析中，感染与较低的出生体重相关。沙眼衣原体的关联不太清楚，阴道毛虫和BV与较低的出生体重无关。生殖器支原体的性传播感染患病率很高（13.9％），淋病奈瑟菌（5.0%），沙眼衣原体（20.0%）；合并感染频繁。对出生体重的较大影响大小与生殖支原体的共感染发生，淋病奈瑟菌,和/或沙眼衣原体。
结论：M.生殖器是降低出生体重的潜在原因，合并感染似乎对出生体重有更大的负面影响。迫切需要进行试验，以检查生殖支原体和其他性传播感染在妊娠和孕前的早期诊断和治疗的影响。
背景：资金来自慈善赠款，国家卫生和医学研究委员会，和伯内特研究所。资助者在研究设计中没有作用，数据收集和分析，决定发布，或准备手稿。
方法：出生体重与生殖支原体和其他性传播感染（沙眼衣原体，淋病奈瑟菌,和阴道毛滴虫）和BV在巴布亚新几内亚的一项前瞻性队列研究中对416对母体-新生儿对进行了检查。
结果：与未感染的女性相比，生殖支原体（-166.9g，95%置信区间[CI]：-324.2至-9.7g，p=0.038）和淋病奈瑟菌（-274.7g，95%CI：-561.9至12.5g，p=0.061）在调整后的分析中，感染与较低的出生体重相关。沙眼衣原体的关联不太清楚，阴道毛虫和BV与较低的出生体重无关。生殖器支原体的性传播感染患病率很高（13.9％），淋病奈瑟菌（5.0%），沙眼衣原体（20.0%）；合并感染频繁。对出生体重的较大影响大小与生殖支原体的共感染发生，淋病奈瑟菌,和/或沙眼衣原体。
结论：M.生殖器是降低出生体重的潜在原因，合并感染似乎对出生体重有更大的负面影响。迫切需要进行试验，以检查生殖支原体和其他性传播感染在妊娠和孕前的早期诊断和治疗的影响。
背景：资金来自慈善赠款，国家卫生和医学研究委员会，和伯内特研究所。资助者在研究设计中没有作用，数据收集和分析，决定发布，或准备手稿。
