Chinese herbal formulas

  • 文章类型: Journal Article
    慢性肾脏病(CKD)是一种隐匿性疾病,由于其高发病率,已成为全球重大公共卫生问题。意识低,诊断率低,预后不良,和高昂的医疗费用。最近的研究表明,CKD的发展与不同程度的铁凋亡特征有关。中药能调节铁代谢,脂质过氧化,抗氧化系统,以抑制铁凋亡和延迟CKD的进展。因此,铁凋亡的干预机制已成为CKD研究的热点之一。中医有着数千年的传统经验和智慧。它注重人体功能的整体调节,能激发人体的抗病能力和恢复能力,在治疗CKD方面具有一定的优势。然而,目前缺乏关于中医干预铁凋亡治疗CKD及CKD铁凋亡发病机制的综合性文章。因此,本文总结了国内外最新研究进展,简要介绍了铁死亡的主要机制,并系统综述了铁性凋亡与CKD的关系。本文综合中医理论与CKD铁死亡的相关研究,包括"虚证"痰浊""和"毒素",并总结了活性成分和中药配方在干预铁蛋白治疗CKD中的研究现状。通过从一个新的角度来考虑铁中毒,本文旨在为中医药治疗CKD提供新的靶点和方向。
    Chronic kidney disease(CKD) is an insidious disease that has become a significant global public health issue due to its high incidence rate, low awareness, low diagnostic rate, poor prognosis, and high medical costs. Recent studies have shown that CKD development is associated with varying degrees of ferroptosis features. Traditional Chinese medicine(TCM) can regulate iron metabolism, lipid peroxidation, antioxidant systems to inhibit ferroptosis and delay the progression of CKD. Consequently, the intervention mechanism of ferroptosis has become one of the focuses of CKD research. TCM has thousands of years of traditional experience and wisdom. It focuses on the overall regulation of human body functions and can stimulate the body\'s disease resistance and recovery capabilities, which has certain advantages in treating CKD. However, there is currently a lack of comprehensive articles on the application of TCM in intervening ferroptosis to treat CKD and the pathogenesis of ferroptosis in CKD. Therefore, this article summarizes the latest research progress both domestically and internationally, briefly introduces the main mechanisms of ferroptosis, and systematically reviews the relationship between ferroptosis and CKD. The article integrates TCM theories related to ferroptosis in CKD, including "deficiency" "stasis" "phlegm turbidity" and "toxins" and summarizes the research status of active ingredients and herbal formulas in intervening ferroptosis to treat CKD. By considering ferroptosis from a new perspective, this article aims to provide new targets and directions for the application of TCM in treating CKD.
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  • 文章类型: Journal Article
    补充二治丸(SEZW)是一种常用于治疗雄激素性脱发(AGA)的传统中药。本研究旨在验证SEZW治疗小鼠AGA的有效性,并利用网络药理学和分子对接技术探索其潜在的分子机制。
    将40只小鼠分为五组:对照组,AGA模型,AGA-阳性,SEZW低剂量,和SEZW高剂量。通过在治疗后第0、14和28天对毛发进行评分并在治疗后第28天对小鼠毛发进行称重来评估小鼠的毛发再生。使用中药数据库获得了SEZW的活性化合物的目标。从五个数据库下载与AGA相关的目标。然后,鉴定了重叠的基因。使用STRING数据库构建蛋白质-蛋白质相互作用网络。通过分析确定了枢纽目标。进行基因本体论(GO)和京都基因和基因组百科全书(KEGG)途径富集分析。最后,进行活性化合物和hub靶标的分子对接。
    SEZW治疗组小鼠的毛发再生相对于AGA模型小鼠显著增强。总共确定了59个潜在的药物-疾病靶标。根据GO/KEGG分析结果,氧化应激和腺体发育被确定为SEZW在AGA治疗中的潜在作用机制。PI3K-Akt和AGE-RAGE信号通路和7个枢纽靶标被鉴定为SEZW功能的潜在潜在潜在机制。分子对接结果显示,最具活性的SEZW化合物稳定地结合几个候选疾病靶标。
    SEZW在小鼠模型中有效治疗AGA。结合网络药理分析,潜在的机制,信号通路,并确定了SEZW在AGA治疗中的枢纽靶标,为进一步研究提供新的思路。
    UNASSIGNED: Supplemented Erzhi Wan (SEZW) is a Traditional Chinese Medicine commonly used in the treatment of androgenetic alopecia (AGA). This study aims to verify the effectiveness of SEZW for the treatment of AGA in mice and explore the potential molecular mechanisms underlying its function using network pharmacology and molecular docking.
    UNASSIGNED: Forty mice were divided into five groups: Control, AGA-model, AGA-Positive, SEZW Low Dose, and SEZW High Dose. Hair regrowth in mice was evaluated by scoring hair on days 0, 14, and 28 post-treatment and weighing mouse hair on day 28 post-treatment. The targets of the active compounds of SEZW were obtained using the Traditional Chinese Medicine Database. AGA-related targets were downloaded from five databases. Then, the overlapping genes were identified. A protein-protein interaction network was constructed using the STRING database. Hub targets were determined through analysis. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed. Finally, molecular docking of active compounds and hub targets was performed.
    UNASSIGNED: Hair regrowth in mice in the SEZW treatment groups was significantly enhanced relative to that in the AGA-model mice. A total of 59 potential drug-disease targets were identified. Based on the GO/KEGG analysis results, oxidative stress and gland development were identified as potential mechanisms of action of SEZW in AGA treatment. The PI3K-Akt and AGE-RAGE signaling pathways and seven hub targets were identified as the potential underlying mechanism of SEZW function. Molecular docking results showed that the most active SEZW compounds bind stably to several of the candidate disease targets.
    UNASSIGNED: SEZW is effective in the treatment of AGA in a mouse model. Combined with network pharmacological analysis, the potential mechanisms, signaling pathways, and hub targets of SEZW in the treatment of AGA were identified, providing new ideas for further studies.
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  • 文章类型: Systematic Review
    未经批准:糖尿病肾病(DKD),广义上定义为糖尿病患者的持续性蛋白尿,估计肾小球滤过率较低,是终末期肾病的主要病因.过量产生活性氧是DKD发病机理的重要机制,许多抗氧化剂已作为治疗剂进行了研究。其中,中药抗氧化应激疗法已被广泛用于对抗DKD,这可能为DKD的治疗发展提供新的见解。西药(WM)的功效与中药(CMF)的功效之间存在一些差异。
    未经授权:我们搜索了PubMed,科克伦图书馆,WebofScience数据库,Embase,和Scopus从开始到2021年12月使用相关关键词,并对随机对照试验(RCT)进行了全面搜索.通过具有随机效应的逆方差方法计算合并加权平均差(MD)和95%CI。所有相关统计分析均使用Stata15.1版软件(StataCorporation)和Rvman5.3版(NordicCochraneCenter)进行。
    UNASSIGNED:共8篇,其中9组包括模型组106篇,CMF组中的105,和99在WM组中。来自8项研究(9组)的汇总数据显示,与模型组[标准化MD(SMD)=1.57;95CI:1.16-1.98;P<0.05]和WM组(SMD=0.56;95CI:0.19-0.92;P<0.05)相比,超氧化物歧化酶有统计学改善。对于谷胱甘肽过氧化物酶(GSH-Px),CMF组与CMF组相比有显著改善模型组和WM组。对于丙二醛(MDA),在CMF组中显著降低(CMF与模型组:SMD=-1.52;95CI:-1.88-1.17;P<0.05;CMFvs.WM组:SMD=-0.64;95CI:-0.95-0.33;P<0.05)。
    UNASSIGNED:本系统综述和荟萃分析表明,CMF治疗对缓解STZ诱导的DKD大鼠的氧化应激有显著疗效,且CMF明显优于WM对照组。对于临床应用,研究结果在一定程度上对CMF的疗效进行评价,为DKD提供了信心和一定的理论参考。
    未经批准:[PROSPERO],标识符[CRD42022313737]。
    UNASSIGNED: Diabetic kidney disease (DKD), defined broadly as persistent proteinuria with low estimated glomerular filtration rate in patients with diabetes, is a main cause of end-stage renal disease. Excessive production of reactive oxygen species is an important mechanism underlying the pathogenesis of DKD and many antioxidants have been investigated as therapeutic agents. Among them, Chinese medicine antioxidative stress therapies have been widely used to combat DKD, which may offer new insights into therapeutic development of DKD. There are several discrepancies among the efficacy of Western medicine (WM) and Chinese medicinal formula (CMF) action.
    UNASSIGNED: We searched PubMed, Cochrane Library, the Web of Science databases, Embase, and Scopus from inception to December 2021 using relevant keywords and a comprehensive search for randomized controlled trials (RCTs) was performed. Calculating the pooled weighted mean difference (MD) and 95% CI by the method of inverse-variance with a random-effect. All the related statistical analyses were performed using Stata version 15.1 software (Stata Corporation) and Rvman version 5.3 (Nordic Cochrane Center).
    UNASSIGNED: A total of 8 articles with the 9 groups including 106 in the model group, 105 in the CMF group, and 99 in the WM group. Pooled data from 8 studies (9 groups) showed a statistical improvement in superoxide dismutase compared with the model group [standardized MD (SMD) = 1.57; 95 CI: 1.16-1.98; P < 0.05] and the WM group (SMD = 0.56; 95 CI: 0.19-0.92; P < 0.05). For glutathione peroxidase (GSH-Px), it was significantly improved in the CMF group vs. the model group and the WM group. For malondialdehyde (MDA), it was significantly reduced in the CMF group (CMF vs. model group: SMD = -1.52; 95 CI: -1.88 -1.17; P < 0.05; CMF vs. WM group: SMD = -0.64; 95 CI: -0.95 -0.33; P < 0.05).
    UNASSIGNED: This systematic review and meta-analysis have demonstrated that the therapy of CMF had a notable curative effect on relieving oxidative stress in STZ-induced DKD rats and CMF was significantly more effective than the WM control group. For the clinical application, the results providing confidence and some theoretical reference for DKD via evaluating the efficacy of CMF to a certain extent.
    UNASSIGNED: [PROSPERO], identifier [CRD42022313737].
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  • 文章类型: Journal Article
    Cardiovascular diseases are one of the leading causes of death worldwide and cardiac fibrosis is a common pathological process for cardiac remodeling in cardiovascular diseases. Cardiac fibrosis not only accelerates the deterioration progress of diseases but also becomes a pivotal contributor for futile treatment in clinical cardiovascular trials. Although cardiac fibrosis is common and prevalent, effective medicines to provide sufficient clinical intervention for cardiac fibrosis are still unavailable. Traditional Chinese medicine (TCM) is the natural essence experienced boiling, fry, and other processing methods, including active ingredients, extracts, and herbal formulas, which have been applied to treat human diseases for a long history. Recently, research has increasingly focused on the great potential of TCM for the prevention and treatment of cardiac fibrosis. Here, we aim to clarify the identified pro-fibrotic mechanisms and intensively summarize the application of TCM in improving cardiac fibrosis by working on these mechanisms. Through comprehensively analyzing, TCM mainly regulates the following pathways during ameliorating cardiac fibrosis: attenuation of inflammation and oxidative stress, inhibition of cardiac fibroblasts activation, reduction of extracellular matrix accumulation, modulation of the renin-angiotensin-aldosterone system, modulation of autophagy, regulation of metabolic-dependent mechanisms, and targeting microRNAs. We also discussed the deficiencies and the development direction of anti-fibrotic therapies on cardiac fibrosis. The data reviewed here demonstrates that TCM shows a robust effect on alleviating cardiac fibrosis, which provides us a rich source of new drugs or drug candidates. Besides, we also hope this review may give some enlightenment for treating cardiac fibrosis in clinical practice.
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  • 文章类型: Journal Article
    OBJECTIVE: To summarize the current evidence for 8 frequently prescribed Chinese herbal formulas (CHF) as treatments for angina pectoris in patients with coronary heart disease (CHD) and the associated adverse reactions.
    METHODS: Seven electronic databases were screened from their inception through July 2018 for all evidence related to classical CHF for the treatment of patients with CHD.
    RESULTS: CHF improves CHD outcomes in terms of angina pectoris, electrocardiogram results, Chinese medicine syndromes and biomarkers iomarkers. The combination of CHF and Western medicine (WM) is more effective on CHD than WM alone. The use of CHF to treat CHD shows the same or better clinical effects as the use of WM alone. The 8 investigated CHF do not induce hepatic and renal toxicity or other serious adverse effects.
    CONCLUSIONS: The safety and efficacy of 8 frequently prescribed herbal formulas for treating CHD have been confirmed in many studies. The findings of these studies are positive but should be interpreted cautiously due to the poor methodological quality of the randomized controlled trials (RCTs) and meta-analyses. Additional high-quality, multi-center, large-sample RCTs should be performed to confirm these results.
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  • 文章类型: Journal Article
    急性胰腺炎(AP)是一种常见的胃肠道疾病。已观察到AP的年发病率增加,导致急性住院和高死亡率。AP的诊断和治疗指南推荐以减少胰腺分泌和继发性损伤为重点的保守药物治疗。作为主要的治疗方法。不幸的是,现有的治疗方案对AP的发病率和严重程度的影响有限,这是由于AP的病理过程复杂和多方面.近几十年来,在亚洲国家,中草药(CHMs)已被用作减轻AP的有效治疗剂。尽管早期细胞培养,动物模型,和临床试验,CHMs能够与许多参与AP发病机制的分子靶标相互作用;然而,全面,该领域的最新通信尚不可用。本文综述了CHMs在体外和体内抗AP的药理活性及其潜在机制。对少数选定和有前途的植物衍生分子(大黄素,黄芩苷,白藜芦醇,姜黄素,川芎嗪,和和厚朴酚)靶向AP中涉及的许多蛋白质或网络最初是基于网络药理学模拟而建立的。此外,我们还总结了一些潜在的胰腺毒性天然产物,以便更安全合理的用药。这些突破性发现可能对创新药物研究和AP治疗的未来发展具有重要意义。
    Acute pancreatitis (AP) is a commonly occurring gastrointestinal disorder. An increase in the annual incidence of AP has been observed, and it causes acute hospitalization and high mortality. The diagnosis and treatment guidelines for AP recommend conservative medical treatments focused on reducing pancreatic secretion and secondary injury, as a primary therapeutic approach. Unfortunately, the existing treatment options have limited impact on the incidence and severity of AP due to the complex and multifaceted pathological process of this disease. In recent decades, Chinese herbal medicines (CHMs) have been used as efficient therapeutic agents to attenuate AP in Asian countries. Despite early cell culture, animal models, and clinical trials, CHMs are capable of interacting with numerous molecular targets participating in the pathogenesis of AP; however, comprehensive, up-to-date communication in this field is not yet available. This review focuses on the pharmacological activities of CHMs against AP in vitro and in vivo and the underlying mechanisms. A computational prediction of few selected and promising plant-derived molecules (emodin, baicalin, resveratrol, curcumin, ligustrazine, and honokiol) to target numerous proteins or networks involved in AP was initially established based on a network pharmacology simulation. Moreover, we also summarized some potential toxic natural products for pancreas in order to more safe and reasonable medication. These breakthrough findings may have important implications for innovative drug research and the future development of treatments for AP.
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  • 文章类型: Case Reports
    BACKGROUND: Acupuncture is an often sought-out treatment modality for migraine. The World Health Organization lists headache as one of the several conditions treated effectively by acupuncture.
    METHODS: This single case reports on a 32-year-old woman who presented with a 10-year history of migraine.
    METHODS: The patient was treated with acupuncture, dietary modifications, and Chinese herbal medicine enemas over a course of 2 months.
    RESULTS: The patient experienced pain relief that resulted in several months without any migraine.
    CONCLUSIONS: This article may aid in expanding practitioners\' treatment options to include a more diverse set of modalities such as Chinese herbal enemas. More research is needed to investigate the role of Oriental medicine and Chinese herbal enemas in the treatment of pain conditions.
    摘要 背景:针灸是偏头痛的一种常见 治疗模式。世界卫生组织将头痛 列为针灸可予有效治疗的多种疾 病之一。案例介绍:此单一案例记述的是 一名拥有 10 年偏头痛病史的 32 岁女性。方法:该患者接受针灸、饮食调 整和中草药灌肠剂治疗,疗程为 2 个月。结果:该患者疼痛减轻,并在数 月时间内未出现偏头痛症状。结论:本文可帮助拓展执业医生 的治疗选项,以便纳入中草药灌 肠剂等更为多样的模式组合。这 需要人们开展更多的研究来调查 东方医学和中草药灌肠剂在痛症 治疗方面所发挥的作用。
    La acupuntura suele ser una modalidad de tratamiento utilizada para la migraña. La Organización Mundial de la Salud enumera el dolor de cabeza como una de las diferentes condiciones tratadas con eficacia por la acupuntura.
    Este único caso informa de una mujer de 32 años que presentaba unos antecedentes de migraña de 10 años.
    Trataron a la paciente con acupuntura, modificaciones dietéticas y enemas de hierbas medicinales chinas durante el transcurso de dos meses.
    La paciente experimentó un alivio del dolor que llevó a varios meses sin ninguna migraña.
    Este artículo puede ayudar a ampliar las opciones de tratamiento de un médico para incluir un sistema más diverso de modalidades como los enemas de hierbas chinas. Es necesario realizar más investigaciones para investigar el papel de la medicina oriental y de los enemas de hierbas chinas en el tratamiento de afecciones dolorosas.
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