Abstract：
Chronic kidney disease(CKD) is an insidious disease that has become a significant global public health issue due to its high incidence rate, low awareness, low diagnostic rate, poor prognosis, and high medical costs. Recent studies have shown that CKD development is associated with varying degrees of ferroptosis features. Traditional Chinese medicine(TCM) can regulate iron metabolism, lipid peroxidation, antioxidant systems to inhibit ferroptosis and delay the progression of CKD. Consequently, the intervention mechanism of ferroptosis has become one of the focuses of CKD research. TCM has thousands of years of traditional experience and wisdom. It focuses on the overall regulation of human body functions and can stimulate the body\'s disease resistance and recovery capabilities, which has certain advantages in treating CKD. However, there is currently a lack of comprehensive articles on the application of TCM in intervening ferroptosis to treat CKD and the pathogenesis of ferroptosis in CKD. Therefore, this article summarizes the latest research progress both domestically and internationally, briefly introduces the main mechanisms of ferroptosis, and systematically reviews the relationship between ferroptosis and CKD. The article integrates TCM theories related to ferroptosis in CKD, including "deficiency" "stasis" "phlegm turbidity" and "toxins" and summarizes the research status of active ingredients and herbal formulas in intervening ferroptosis to treat CKD. By considering ferroptosis from a new perspective, this article aims to provide new targets and directions for the application of TCM in treating CKD.
摘要：
慢性肾脏病(CKD)是一种隐匿性疾病,由于其高发病率,已成为全球重大公共卫生问题。意识低,诊断率低,预后不良,和高昂的医疗费用。最近的研究表明，CKD的发展与不同程度的铁凋亡特征有关。中药能调节铁代谢,脂质过氧化，抗氧化系统，以抑制铁凋亡和延迟CKD的进展。因此,铁凋亡的干预机制已成为CKD研究的热点之一。中医有着数千年的传统经验和智慧。它注重人体功能的整体调节，能激发人体的抗病能力和恢复能力，在治疗CKD方面具有一定的优势。然而,目前缺乏关于中医干预铁凋亡治疗CKD及CKD铁凋亡发病机制的综合性文章。因此,本文总结了国内外最新研究进展，简要介绍了铁死亡的主要机制，并系统综述了铁性凋亡与CKD的关系。本文综合中医理论与CKD铁死亡的相关研究,包括"虚证"痰浊""和"毒素"，并总结了活性成分和中药配方在干预铁蛋白治疗CKD中的研究现状。通过从一个新的角度来考虑铁中毒，本文旨在为中医药治疗CKD提供新的靶点和方向。
