碘的摄入会影响甲状腺和乳腺细胞,尿碘浓度(UIC)是碘摄入量的有效生物标志物。
目的:本研究旨在分析分化型甲状腺癌(DTC)与乳腺癌(BC)患者尿碘浓度的相关性。
方法:该研究由80名受试者组成,分为病例(20名DTC受试者和20名BC受试者)和对照(40名受试者)。晨尿或斑点尿用于UIC测量。
结果:在甲状腺癌中,UIC患者和对照组的中位数为195.45±133.61µg/L和145±39.64µg/L,分别,p=0.33PTC受试者的UIC中位数明显高于FTC受试者,227.12±130.98μg/L与68.75±22.95μg/L,p=0.00,甲状腺乳头状癌与尿中高碘排泄密切相关,应急系数(c)=0.722。在BC患者中,不管亚型,乳腺癌患者的碘排泄水平明显降低.UIC患者和对照组的中位数分别为80.05±38.24µg/L和144.25±36.79µg/L,分别,p=0.000。
结论:碘尿浓度与DTC组织病理学类型密切相关,在BC科目中,与对照相比,IUC显著较低。
Iodine intake can affect thyroid and breast cells, and urinary iodine concentration (UIC) is an effective biomarker for iodine intake.
OBJECTIVE: This study aimed to analyze the correlation between urinary iodine concentration in differentiated thyroid cancer (DTC) and breast cancer (BC) subjects.
METHODS: The study consisted of 80 subjects divided into case (20 DTC and 20 BC subjects) and control (40 subjects). Morning urine or spot urine was used for UIC measurement.
RESULTS: In thyroid cancer, UIC median patients and controls were 195.45 ± 133.61 µg/L and 145 ± 39.64 µg/L, respectively, with p =0.33. The UIC median of PTC subjects was significantly higher compared to FTC subjects, 227.12±130.98 μg/L versus 68.75±22.95 μg/L, p=0.00, and papillary thyroid cancer is closely related to a high iodine excretion in urine with contingency coefficient (c)=0.722. In BC patients, regardless of subtypes, breast cancer subjects showed a significantly lower iodine excretion level. The median of UIC patients and controls were 80.05 ± 38.24 µg/L and 144.25 ± 36.79 µg/L, respectively, p=0.000.
CONCLUSIONS: Iodine urine concentrations strongly correlate with the type of DTC histopathology, and in BC subjects, IUC was significantly lower compared to the control.