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Abstract：
Background and Objectives: The pancreatic solid pseudopapillary neoplasm (SPN), a rare tumor predominantly affecting young women, has seen an increased incidence due to improved imaging and epidemiological knowledge. This study aimed to understand the outcomes of different interventions, possible complications, and associated risk factors. Materials and Methods: This study retrospectively analyzed 24 patients who underwent pancreatic surgery for SPNs between September 1998 and July 2020. Results: Surgical intervention, typically required for symptomatic cases or pathological confirmation, yielded favorable outcomes with a 5-year survival rate of up to 97%. Despite challenges in standardizing preoperative evaluation and follow-up protocols, aggressive complete resection showed promising long-term survival and good oncological outcomes. Notably, no significant differences were found between conventional and minimally invasive (MI) surgery in perioperative outcomes. Histopathological correlations were lacking in prognosis and locations. Among the patients, one developed diffuse liver metastases 41 months postoperatively but responded well to chemotherapy and transcatheter arterial chemoembolization, with disease stability observed at 159 postoperative months. Another patient developed nonalcoholic steatohepatitis after surgery and underwent liver transplantation, succumbing to poor medication adherence 115 months after surgery. Conclusions: These findings underscore the importance of surgical intervention in managing SPNs and suggest the MI approach as a viable option with comparable outcomes to conventional surgery.
摘要：
背景与目的:胰腺实性假乳头状瘤(SPN),一种主要影响年轻女性的罕见肿瘤，由于影像学和流行病学知识的改善，发病率增加。本研究旨在了解不同干预措施的结果，可能的并发症,和相关的危险因素。材料和方法：本研究回顾性分析了1998年9月至2020年7月期间接受SPN胰腺手术的24例患者。结果：手术干预，通常需要有症状的病例或病理证实，结果良好,5年生存率高达97%.尽管在标准化术前评估和随访方案方面存在挑战，侵袭性完全切除显示有希望的长期生存率和良好的肿瘤结局.值得注意的是,常规手术和微创(MI)手术的围手术期结局无显著差异.预后和位置缺乏组织病理学相关性。在患者中,1例患者术后41个月出现弥漫性肝转移,但化疗和肝动脉化疗栓塞反应良好,术后159个月观察到疾病稳定性。另一位患者在手术后发展为非酒精性脂肪性肝炎，并接受了肝移植，手术后115个月屈服于不良的药物依从性。结论：这些发现强调了手术干预在管理SPN中的重要性，并建议MI方法是一种可行的选择，其结果与常规手术相当。
