{Reference Type}: Journal Article
{Title}: Analysis of Urinary Iodine Concentration in Differentiated Thyroid Cancer and Breast Cancer Cases.
{Author}: Kurniawati Y;Erdiansari Y;Putra NA;Khambri D;Asyari A;Irrahmah M;Elliyanti A;
{Journal}: Asian Pac J Cancer Prev
{Volume}: 25
{Issue}: 6
{Year}: 2024 Jun 1
暂无{DOI}: 10.31557/APJCP.2024.25.6.1869
{Abstract}: Iodine intake can affect thyroid and breast cells, and urinary iodine concentration (UIC) is an effective biomarker for iodine intake.<BR><B>OBJECTIVE: </B>This study aimed to analyze the correlation between urinary iodine concentration in differentiated thyroid cancer (DTC) and breast cancer (BC) subjects.<BR><B>METHODS: </B>The study consisted of 80 subjects divided into case (20 DTC and 20 BC subjects) and control (40 subjects). Morning urine or spot urine was used for UIC measurement.<BR><B>RESULTS: </B>In thyroid cancer, UIC median patients and controls were 195.45 ± 133.61 µg/L and 145 ± 39.64 µg/L, respectively, with p =0.33. The UIC median of PTC subjects was significantly higher compared to FTC subjects, 227.12±130.98 μg/L versus 68.75±22.95 μg/L, p=0.00, and papillary thyroid cancer is closely related to a high iodine excretion in urine with contingency coefficient  (c)=0.722. In BC patients, regardless of subtypes, breast cancer subjects showed a significantly lower iodine excretion level. The median of UIC patients and controls were 80.05 ± 38.24 µg/L and 144.25 ± 36.79 µg/L, respectively, p=0.000.<BR><B>CONCLUSIONS: </B>Iodine urine concentrations strongly correlate with the type of DTC histopathology, and in BC subjects, IUC was significantly lower compared to the control.