■南佛罗里达浸信会健康的迈阿密心脏研究(MiHeart)正在进行中,以社区为基础,前瞻性队列研究旨在表征患病率,特点,早期亚临床冠状动脉粥样硬化和各种潜在人口统计学指标的预后价值,社会心理,和代谢危险因素。我们提出了研究目标,详细的研究方法,和MiHeart的初步基线结果。
MiHeart从大迈阿密地区的普通人群中招募了2,459名中年男性和女性参与者。招募时间为2015年5月至2018年9月,仅限于40-65岁无临床心血管疾病(CVD)的参与者。基线检查包括人口统计学评估,生活方式,病史,和心理社会特征的详细评估;全面的身体检查;测量多种血液生物标志物,包括炎症的措施,高级脂质测试,和基因组学;使用冠状动脉计算机断层扫描血管造影术评估亚临床冠状动脉粥样硬化斑块和血管功能,冠状动脉钙积分,颈动脉内膜中层厚度,脉搏波速度,和外周动脉张力测量法;以及其他测试,包括12导联心电图和肺功能评估。将血液样本进行生物分析,以促进未来的辅助研究。
MiHeart招募了1,261名男性(51.3%)和1,198名女性(48.7%)。平均年龄53岁,85.6%的参与者是白人,47.4%的参与者是西班牙裔/拉丁裔。这项研究包括7%的糖尿病患者,33%患有高血压,15%的患者在基线时使用他汀类药物治疗.超重或肥胖的参与者占人口的72%,吸烟者占3%。使用集合队列方程估计的10年动脉粥样硬化CVD风险中位数为4%。
■MiHeart将提供重要的,对早期亚临床动脉粥样硬化的病理生理学的新见解,并进一步了解其在临床CVD发生中的作用。研究结果将具有重要意义,进一步完善当前的心血管预防范式以及风险评估和管理方法。
UNASSIGNED: The Miami Heart Study (MiHeart) at Baptist Health South Florida is an ongoing, community-based, prospective cohort study aimed at characterizing the prevalence, characteristics, and prognostic value of diverse markers of early subclinical coronary atherosclerosis and of various potential demographic, psychosocial, and metabolic risk factors. We present the study objectives, detailed research methods, and preliminary baseline results of MiHeart.
UNASSIGNED: MiHeart enrolled 2,459 middle-aged male and female participants from the general population of the Greater Miami Area. Enrollment occurred between May 2015 and September 2018 and was restricted to participants aged 40-65 years free of clinical cardiovascular disease (CVD). The baseline examination included assessment of demographics, lifestyles, medical history, and a detailed evaluation of psychosocial characteristics; a comprehensive physical exam; measurement of multiple blood biomarkers including measures of inflammation, advanced lipid testing, and genomics; assessment of subclinical coronary atherosclerotic plaque and vascular function using coronary computed tomography angiography, the coronary artery calcium score, carotid intima-media thickness, pulse wave velocity, and peripheral arterial tonometry; and other tests including 12-lead electrocardiography and assessment of pulmonary function. Blood samples were biobanked to facilitate future ancillary research.
UNASSIGNED: MiHeart enrolled 1,261 men (51.3%) and 1,198 women (48.7%). Mean age was 53 years, 85.6% participants were White and 47.4% were of Hispanic/Latino ethnicity. The study included 7% individuals with diabetes, 33% with hypertension, and 15% used statin therapy at baseline. Overweight or obese participants comprised 72% of the population and 3% were smokers. Median 10-year estimated atherosclerotic CVD risk using the Pooled Cohort Equations was 4%.
UNASSIGNED: MiHeart will provide important, novel insights into the pathophysiology of early subclinical atherosclerosis and further our understanding of its role in the genesis of clinical CVD. The study findings will have important implications, further refining current cardiovascular prevention paradigms and risk assessment and management approaches moving forward.