{Reference Type}: Journal Article
{Title}: Cardiovascular Manifestations From Therapeutic Radiation: A Multidisciplinary Expert Consensus Statement From the International Cardio-Oncology Society.
{Author}: Mitchell JD;Cehic DA;Morgia M;Bergom C;Toohey J;Guerrero PA;Ferencik M;Kikuchi R;Carver JR;Zaha VG;Alvarez-Cardona JA;Szmit S;Daniele AJ;Lopez-Mattei J;Zhang L;Herrmann J;Nohria A;Lenihan DJ;Dent SF;
{Journal}: JACC CardioOncol
{Volume}: 3
{Issue}: 3
{Year}: Sep 2021
{Factor}: 8.422
{DOI}: 10.1016/j.jaccao.2021.06.003
{Abstract}: Radiation therapy is a cornerstone of cancer therapy, with >50% of patients undergoing therapeutic radiation. As a result of widespread use and improved survival, there is increasing focus on the potential long-term effects of ionizing radiation, especially cardiovascular toxicity. Radiation therapy can lead to atherosclerosis of the vasculature as well as valvular, myocardial, and pericardial dysfunction. We present a consensus statement from the International Cardio-Oncology Society based on general principles of radiotherapy delivery and cardiovascular risk assessment and risk mitigation in this population. Anatomical-based recommendations for cardiovascular management and follow-up are provided, and a priority is given to the early detection of atherosclerotic vascular disease on imaging to help guide preventive therapy. Unique management considerations in radiation-induced cardiovascular disease are also discussed. Recommendations are based on the most current literature and represent a unanimous consensus by the multidisciplinary expert panel.