PDF(Pubmed)
Abstract：
UNASSIGNED: Coronary artery calcium score (CAC) is a validated tool to predict and reclassify cardiovascular risk. Additional metrics such as regional distribution and extent of CAC over Agatston CAC score may allow further risk stratification. In this study, we evaluate the prognostic significance of proximal CAC involvement in asymptomatic population from the prospective EISNER (Early-Identification of Subclinical Atherosclerosis by Noninvasive Imaging Research) registry, focusing on patients with mild CAC (score 1-99).
UNASSIGNED: This study included a total of 2,047 adult asymptomatic subject who underwent baseline CAC scan and 14-year follow-up for MACE, defined as myocardial infarction, late revascularization, or cardiac death. Proximal involvement was defined as presence of CAC in the LM, proximal LAD, LCX or RCA. CAC was categorized as 0, 1-99, and ≥100.
UNASSIGNED: 1,090 (53.2%) subjects had no CAC, 576 (28.1%) had CAC 1-99, and 381 (18.7%) had CAC ≥100. Proximal involvement was seen in 67.2% of subjects with CAC 1-99 and 97.3% of subjects with CAC ≥100. In the CAC 1-99 category, the presence of proximal CAC was associated with increased MACE risk after adjustment for CAC score, CAC extent and conventional risk factors compared to those without proximal CAC (HR: 2.84 95% CI: 1.29-6.25, p=0.009).
UNASSIGNED: In asymptomatic subjects with CAC scores of 1-99, the presence and extent of proximal CAC plaques provides strong independent prognostic information in predicting MACE.
UNASSIGNED: This study included a total of 2,047 adult asymptomatic subject who underwent baseline CAC scan and 14-year follow-up for MACE, defined as myocardial infarction, late revascularization, or cardiac death. Proximal involvement was defined as presence of CAC in the LM, proximal LAD, LCX or RCA. CAC was categorized as 0, 1-99, and ≥100.
UNASSIGNED: 1,090 (53.2%) subjects had no CAC, 576 (28.1%) had CAC 1-99, and 381 (18.7%) had CAC ≥100. Proximal involvement was seen in 67.2% of subjects with CAC 1-99 and 97.3% of subjects with CAC ≥100. In the CAC 1-99 category, the presence of proximal CAC was associated with increased MACE risk after adjustment for CAC score, CAC extent and conventional risk factors compared to those without proximal CAC (HR: 2.84 95% CI: 1.29-6.25, p=0.009).
UNASSIGNED: In asymptomatic subjects with CAC scores of 1-99, the presence and extent of proximal CAC plaques provides strong independent prognostic information in predicting MACE.
摘要：
未经评估：冠状动脉钙积分（CAC）是预测和重新分类心血管风险的有效工具。其他指标（如AgatstonCAC评分的区域分布和CAC程度）可能允许进一步的风险分层。在这项研究中,我们从前瞻性EISNER（通过非侵入性成像研究对亚临床动脉粥样硬化的早期识别）注册中评估无症状人群中近端CAC受累的预后意义，关注轻度CAC患者（评分1-99）。
UNASSIGNED：本研究共纳入2,047名成人无症状受试者，他们接受了基线CAC扫描和14年MACE随访，定义为心肌梗塞，晚期血运重建,或心脏死亡。近端受累定义为LM中存在CAC，近端LAD,LCX或RCA。CAC分为0、1-99和≥100。
未经评估：1,090（53.2％）受试者没有CAC，576例（28.1%）CAC1-99，381例（18.7%）CAC≥100。在67.2％的CAC1-99受试者和97.3％的CAC≥100受试者中观察到近端受累。在CAC1-99类别中，校正CAC评分后,近端CAC的存在与MACE风险增加相关,与没有近端CAC的CAC程度和常规危险因素相比（HR：2.8495％CI：1.29-6.25，p=0.009）。
UNASSIGNED：在CAC评分为1-99的无症状受试者中，近端CAC斑块的存在和程度为预测MACE提供了强有力的独立预后信息。
UNASSIGNED：本研究共纳入2,047名成人无症状受试者，他们接受了基线CAC扫描和14年MACE随访，定义为心肌梗塞，晚期血运重建,或心脏死亡。近端受累定义为LM中存在CAC，近端LAD,LCX或RCA。CAC分为0、1-99和≥100。
未经评估：1,090（53.2％）受试者没有CAC，576例（28.1%）CAC1-99，381例（18.7%）CAC≥100。在67.2％的CAC1-99受试者和97.3％的CAC≥100受试者中观察到近端受累。在CAC1-99类别中，校正CAC评分后,近端CAC的存在与MACE风险增加相关,与没有近端CAC的CAC程度和常规危险因素相比（HR：2.8495％CI：1.29-6.25，p=0.009）。
UNASSIGNED：在CAC评分为1-99的无症状受试者中，近端CAC斑块的存在和程度为预测MACE提供了强有力的独立预后信息。
