UNASSIGNED: This study included a total of 2,047 adult asymptomatic subject who underwent baseline CAC scan and 14-year follow-up for MACE, defined as myocardial infarction, late revascularization, or cardiac death. Proximal involvement was defined as presence of CAC in the LM, proximal LAD, LCX or RCA. CAC was categorized as 0, 1-99, and ≥100.
UNASSIGNED: 1,090 (53.2%) subjects had no CAC, 576 (28.1%) had CAC 1-99, and 381 (18.7%) had CAC ≥100. Proximal involvement was seen in 67.2% of subjects with CAC 1-99 and 97.3% of subjects with CAC ≥100. In the CAC 1-99 category, the presence of proximal CAC was associated with increased MACE risk after adjustment for CAC score, CAC extent and conventional risk factors compared to those without proximal CAC (HR: 2.84 95% CI: 1.29-6.25, p=0.009).
UNASSIGNED: In asymptomatic subjects with CAC scores of 1-99, the presence and extent of proximal CAC plaques provides strong independent prognostic information in predicting MACE.
UNASSIGNED:本研究共纳入2,047名成人无症状受试者,他们接受了基线CAC扫描和14年MACE随访,定义为心肌梗塞,晚期血运重建,或心脏死亡。近端受累定义为LM中存在CAC,近端LAD,LCX或RCA。CAC分为0、1-99和≥100。
未经评估:1,090(53.2%)受试者没有CAC,576例(28.1%)CAC1-99,381例(18.7%)CAC≥100。在67.2%的CAC1-99受试者和97.3%的CAC≥100受试者中观察到近端受累。在CAC1-99类别中,校正CAC评分后,近端CAC的存在与MACE风险增加相关,与没有近端CAC的CAC程度和常规危险因素相比(HR:2.8495%CI:1.29-6.25,p=0.009)。
UNASSIGNED:在CAC评分为1-99的无症状受试者中,近端CAC斑块的存在和程度为预测MACE提供了强有力的独立预后信息。