■在这项研究中,我们调查了有和没有COVID-19的精神分裂症患者的临床生化值和线粒体质量的差异,从而为COVID-19阳性精神分裂症患者的治疗和管理提供帮助.
■我们进行了探索,12月患者数据的回顾性回顾6,2022,1月2023年31日。在此期间,共确定了1696名精神病住院患者(921名精神分裂症患者和775名被诊断为其他精神疾病)。最后,60名精神分裂症患者被纳入我们的研究,其中20例感染了冠状病毒2综合征(SARS-CoV-2)。分析所有精神分裂症患者的血清生化水平和T淋巴细胞的单细胞线粒体质量(SCMM)。
■血清谷草转氨酶(AST)水平,碱性磷酸酶(ALP),COVID-19(SCZ-C)组精神分裂症患者的肌酐(Cr)和乳酸脱氢酶(LDH)明显升高。此外,SCZ-C组显示较低的CD3+,SCZ组T淋巴细胞的CD3+CD4+和CD3+CD8+细胞计数较SCMM高。此外,在阳性和阴性综合征量表(PANSS)上,T细胞亚群计数与阳性症状评分呈正相关。
■我们的研究结果表明,患有COVID-19的精神分裂症患者具有T淋巴细胞线粒体损伤的表型和较高的血清AST水平,ALP,Cr和LDH,这可能为在随后的传染病传播期间治疗精神分裂症患者提供证据。
UNASSIGNED: In this study, we investigated the differences in clinical biochemical values and mitochondrial mass between schizophrenia patients with and without COVID-19, so as to provide assistance to the treatment and management of COVID-19 positive patients with schizophrenia.
UNASSIGNED: We undertook an exploratory, retrospective review of patient data from Dec. 6, 2022, to Jan. 31, 2023. A total of 1696 inpatients with psychosis (921 schizophrenia patients and 775 diagnosed with other mental diseases) during this period were identified. Finally, 60 schizophrenia patients were enrolled in our study, and 20 of them were infected with syndrome coronavirus 2 (SARS-CoV-2). The serum biochemical levels and single-cell mitochondrial mass (SCMM) of the T lymphocytes of all schizophrenia patients were analyzed.
UNASSIGNED: The serum levels of aspartate aminotransferase (AST), alkaline phosphatase (ALP), creatinine (Cr) and lactate dehydrogenase (LDH) were significantly higher in schizophrenia patients with COVID-19 (SCZ-C) group. In addition, the SCZ-C group showed lower CD3+, CD3+CD4+ and CD3+CD8+ cell counts and higher SCMM of T lymphocytes compared to SCZ group. Furthermore, positive correlations were found between the T-cell subpopulation counts and positive symptom scores on the Positive and Negative Syndrome Scale (PANSS).
UNASSIGNED: Our study findings showed that schizophrenia patients with COVID-19 have a phenotype of mitochondrial damage in T lymphocytes and higher serum levels of AST, ALP, Cr and LDH, which might provide evidence for treating individuals with schizophrenia during subsequent spread of infectious disease.