背景:慢性荨麻疹(CU)与几种系统性和自身免疫性疾病有关。然而,与特应性疾病的联系是有争议的。这项研究的目的是进行系统评价和荟萃分析,以评估CU与特应性疾病之间的关联:特应性皮炎(AD)。哮喘,和过敏性鼻结膜炎(ARC)。
方法:从PubMed搜索命中,Embase,科克伦图书馆,和WebofScience进行了系统的审查。从2000年至今的英语论文,包含关联的原始数据(患病率,发病率,或风险)CU和任何特应性疾病之间,包括在内。使用随机效应模型计算具有95%置信区间的汇集点患病率和OR。
结果:共筛选并审查了8,108个搜索命中。38项研究符合所有纳入标准。估计的AD合并点患病率,哮喘,CU中的ARC为7%(5-11%,I2=99%),12%(9-15%,I2=100%),和22%(16-29%,I2=100%),分别。AD的合并OR估计为2.75(2.05-3.68,I2=94%),1.87(1.01-3.45,I2=100%)用于哮喘,ARC为2.94(1.84-4.68,I2=100%)。
结论:CU中特应性疾病的汇总点患病率与普通人群相当。然而,将患病率与来自相同人群的对照组进行比较的研究均发现CU中特应性疾病的风险显著增加.然而,应谨慎解释结果,因为在所有分析中都发现了高异质性。
BACKGROUND: Chronic urticaria (CU) has been associated with several systemic and autoimmune disorders. The association with atopic disorders is however controversial. The objective of this study was to perform a systematic review and meta-analysis to assess the association between CU and the atopic disorders: atopic dermatitis (AD), asthma, and allergic rhinoconjunctivitis (ARC).
METHODS: Search hits from PubMed, Embase, Cochrane Library, and Web of Science were systematically reviewed. English papers from 2000 to present, containing original data of the association (prevalence, incidence, or risk) between CU and any atopic disorder(s), were included. Pooled point prevalence and OR with 95% confidence intervals were calculated with a random effects model.
RESULTS: A total of 8,108 search hits were screened and reviewed. Thirty-eight studies met all inclusion criteria. The estimated pooled point prevalence of AD, asthma, and ARC in CU was 7% (5-11%, I2 = 99%), 12% (9-15%, I2 = 100%), and 22% (16-29%, I2 = 100%), respectively. Pooled ORs were estimated to 2.75 (2.05-3.68, I2 = 94%) for AD, 1.87 (1.01-3.45, I2 = 100%) for asthma, and 2.94 (1.84-4.68, I2 = 100%) for ARC.
CONCLUSIONS: Pooled point prevalences of atopic disorders in CU were comparable to the general population. However, studies that compared prevalences with controls from the same population all found a significantly increased risk of atopic disorders in CU. Results should however be interpreted with caution as high heterogeneity was found in all analyses.