自2019年底2019年冠状病毒病(COVID-19)爆发以来,它已经在全球造成数百万人死亡。即使没有受到这种疾病困扰的人也不能幸免于它的负面经济,社会,和健康相关的缺点。这篇评论提供了对当前大流行期间抑郁和情绪消极情绪升级的潜在机制的见解。特别是,COVID-19的预防措施,如呆在家里,是减少体力活动的镇静学措施。身体不活动改变肠道微生物组结构,促进肠道生态失调和全身炎症的爆发,导致体内脂肪堆积。肥胖,这导致了一系列损害健康的疾病,促进肠道微生物的分解,而脂肪组织刺激细胞因子的释放,促进代谢抵抗,并改变参与抗氧化剂生产的信号。因此,身体被有毒分子淹没,如促炎症介质,自由基,和晚期糖基化终产物。这些有毒分子改变所有身体组织的细胞功能,包括那些大脑。神经炎症与认知和运动功能的进行性下降以及情绪失调有关。通过参与适当的室内活动和健康食物的摄入来抵消COVID-19大流行所造成的镇静型观念,可能会防止或恢复可能影响在当前危机期间返回家园的人们的生理损伤,最终恢复身心健康。
Ever since the outbreak of Coronavirus disease 2019 (COVID-19) in late 2019, it has killed millions of people worldwide. Even people not stricken by this disease are not spared from its negative economic, social, and health-related drawbacks. This commentary provides insight into the potential mechanisms involved in the development of depression and emotional negativity escalating during the current pandemic. In particular, preventive measures of COVID-19, such as staying at home, are sedentarism measures that decrease physical activity. Physical inactivity alters gut microbiome structure in a fashion that promotes gut dysbiosis and flaring of systemic inflammation, leading to the buildup of body fat. Obesity, which contributes to a trail of health-depleting disorders, furthers gut microbial disintegration while fat tissue stimulates the release of cytokines, promotes metabolic resistance, and alters signaling involved in the production of antioxidants. As a result, the body gets flooded by toxic molecules such pro-inflammatory mediators, free radicals, and advanced glycation end products. These toxic molecules alter cellular function in all body tissues, including those of the brain. Neuroinflammation is associated with progressive declines in cognitive and motor functions along with dysregulation in emotions. Counteracting the sedentarism enforced by the COVID-19 pandemic through the participation in suitable indoors activities and the intake of healthy food is likely to protect against or revert physiological impairments that may affect people retreating to their homes during the current crisis, eventually restoring physical and mental health.