空间分辨代谢组学通过质谱成像揭示糖尿病肾病中组织特异性代谢重编程。
关键词: ADP, adenosine diphosphate AFADESI, air flow-assisted desorption electrospray ionization AGEs, advanced glycation end products AMP, adenosine monophosphate AMPK, adenosine monophosphate activated protein kinase AST, astragaloside IV ATP, adenosine triphosphate Astragaloside IV BUN, blood urea nitrogen CL, cardiolipin Cre, creatinine DAG, diacylglycerol DESI, desorption electrospray ionization DM, diabetes mellitus DN, diabetic nephropathy DPA, docosapentaenoic acid Diabetic nephropathy ESKD, end-stage kidney disease FBG, fasting blood glucose GLU, glucose GMP, guanosine monophosphate GSH, glutathione H&E, hematoxylin and eosin HPLC, high-performance liquid chromatography HbA1c, glycosylated hemoglobin LysoPC, lysophosphatidylcholine LysoPG, lysophosphatidylglycerol MALDI, matrix-assisted laser desorption ionization MS, mass spectrometry MSI, mass spectrometry imaging Mass spectrometry imaging Metabolic reprogramming NMR, nuclear magnetic resonance Na-CMC, sodium carboxymethyl cellulose PA, phosphatidic acid PC, phosphatidylcholine PE, phosphatidylethanolamine PG, phosphatidylglycerol PPP, pentose phosphate pathway PS, phosphatidylserine PUFA, polyunsaturated fatty acids ROI, regions of interest ROS, reactive oxygen species SDH, succinate dehydrogenase SGLTs, sodium-glucose cotransporters SM, sphingomyelin STZ, streptozotocin Spatial-resolved metabolomics TCA, tricarboxylic acid TCHO, total cholesterol TG, triglyceride UMP, uridine monophosphate VIP, variable importance in projection p-AMPK, phosphorylated adenosine monophosphate activated protein kinase ADP, adenosine diphosphate AFADESI, air flow-assisted desorption electrospray ionization AGEs, advanced glycation end products AMP, adenosine monophosphate AMPK, adenosine monophosphate activated protein kinase AST, astragaloside IV ATP, adenosine triphosphate Astragaloside IV BUN, blood urea nitrogen CL, cardiolipin Cre, creatinine DAG, diacylglycerol DESI, desorption electrospray ionization DM, diabetes mellitus DN, diabetic nephropathy DPA, docosapentaenoic acid Diabetic nephropathy ESKD, end-stage kidney disease FBG, fasting blood glucose GLU, glucose GMP, guanosine monophosphate GSH, glutathione H&E, hematoxylin and eosin HPLC, high-performance liquid chromatography HbA1c, glycosylated hemoglobin LysoPC, lysophosphatidylcholine LysoPG, lysophosphatidylglycerol MALDI, matrix-assisted laser desorption ionization MS, mass spectrometry MSI, mass spectrometry imaging Mass spectrometry imaging Metabolic reprogramming NMR, nuclear magnetic resonance Na-CMC, sodium carboxymethyl cellulose PA, phosphatidic acid PC, phosphatidylcholine PE, phosphatidylethanolamine PG, phosphatidylglycerol PPP, pentose phosphate pathway PS, phosphatidylserine PUFA, polyunsaturated fatty acids ROI, regions of interest ROS, reactive oxygen species SDH, succinate dehydrogenase SGLTs, sodium-glucose cotransporters SM, sphingomyelin STZ, streptozotocin Spatial-resolved metabolomics TCA, tricarboxylic acid TCHO, total cholesterol TG, triglyceride UMP, uridine monophosphate VIP, variable importance in projection p-AMPK, phosphorylated adenosine monophosphate activated protein kinase
来 源:
DOI:10.1016/j.apsb.2021.05.013
PDF(Sci-hub)
PDF(Pubmed)