PDF(Pubmed)
Abstract：
Aging, a complex physiological process affecting all living things, is a major area of research, particularly focused on interventions to slow its progression. This study assessed the antiaging efficacy of dapagliflozin (DAPA) on various aging-related parameters in a mouse model artificially induced to age. Forty male Swiss albino mice were randomly divided into four groups of ten animals each. The control group (Group I) received normal saline. The aging model group (Group II) was administered D-galactose orally at 500mg/kg to induce aging. Following the aging induction, the positive control group received Vitamin C supplementation (Group III), while the DAPA group (Group IV) was treated with dapagliflozin. The inflammatory mediators (TNF-α and IL-1β) showed similar patterns of change. No statistically significant difference was observed between groups III and IV. Both groups had significantly lower values compared to GII, while it was significantly higher compared to GI. Glutathione peroxidase (GSH-Px) showed no statistically significant difference between groups GIII and GIV, but it was higher in GIII compared to GII and significantly lower in GIII compared to GI. The study demonstrated that dapagliflozin exerts a beneficial impact on many indicators of aging in mice. The intervention resulted in a reduction in hypertrophy in cardiomyocytes, an enhancement in skin vitality, a decrease in the presence of inflammatory mediators, and an improvement in the efficacy of antioxidants.
摘要：
衰老,影响所有生物的复杂生理过程，是一个主要的研究领域，特别关注减缓其进展的干预措施。这项研究评估了达格列净（DAPA）对人工诱导衰老的小鼠模型中各种衰老相关参数的抗衰老功效。将40只雄性瑞士白化病小鼠随机分为四组，每组十只动物。对照组(I组)接受生理盐水。衰老模型组(Ⅱ组)口服D-半乳糖500mg/kg诱导衰老。在老化诱导之后，阳性对照组接受维生素C补充剂（第三组），而DAPA组（IV组）接受达格列净治疗。炎症介质（TNF-α和IL-1β）显示出相似的变化模式。在III组和IV组之间没有观察到统计学上的显著差异。与GII相比，两组的数值均明显较低，虽然与GI相比明显更高。谷胱甘肽过氧化物酶(GSH-Px)在GIII组和GIV组之间无统计学差异,但是与GII相比，GIII中的GIII更高，而与GI相比，GIII中的GIII明显更低。研究表明，达格列净对小鼠衰老的许多指标都有有益的影响。干预导致心肌细胞肥大减少，增强皮肤活力，炎症介质的存在减少，和改善抗氧化剂的功效。
