PDF(Pubmed)
Abstract：
Diabetes mellitus (DM) is one of the most serious threats in the 21th century throughout the human population that needs to be addressed cautiously. Nowadays, stem cell injection is considered among the most promising protocols for DM therapy; owing to its marked tissues and organs repair capability. Therefore, our 4 weeks study was undertaken to elucidate the probable beneficial effects of two types of adult mesenchymal stem cells (MSCs) on metabolism disturbance and some tissue function defects in diabetic rats. Animals were classified into 4 groups; the control group, the diabetic group, the diabetic group received a single dose of adipose tissue-derived MSCs and the diabetic group received a single dose of bone marrow-derived MSCs. Herein, both MSCs treated groups markedly reduced hyperglycemia resulting from diabetes induction via lowering serum glucose and rising insulin and C-peptide levels, compared to the diabetic group. Moreover, the increased lipid fractions levels were reverted back to near normal values as a consequence to MSCs injection compared to the diabetic untreated rats. Furthermore, both MSCs types were found to have hepato-renal protective effects indicated through the decreased serum levels of both liver and kidney functions markers in the treated diabetic rats. Taken together, our results highlighted the therapeutic benefits of both MSCs types in alleviating metabolic anomalies and hepato-renal diabetic complications.
摘要：
糖尿病（DM）是21世纪人类最严重的威胁之一，需要谨慎应对。如今,干细胞注射被认为是DM治疗最有前途的方案之一;由于其显著的组织和器官修复能力。因此,我们进行了为期4周的研究，以阐明两种成体间充质干细胞（MSCs）对糖尿病大鼠代谢紊乱和某些组织功能缺陷的可能有益作用。动物分为4组;对照组,糖尿病组，糖尿病组接受单剂量脂肪组织来源的MSCs,糖尿病组接受单剂量骨髓来源的MSCs.在这里，两个MSCs治疗组通过降低血清葡萄糖和升高胰岛素和C肽水平显著降低糖尿病诱导引起的高血糖,与糖尿病组相比。此外，与未治疗的糖尿病大鼠相比,由于MSC注射,增加的脂质分数水平恢复到接近正常值.此外，发现两种类型的MSCs均具有肝肾保护作用,这通过治疗的糖尿病大鼠中肝脏和肾脏功能标志物的血清水平降低来表明.一起来看,我们的结果强调了两种MSCs在缓解代谢异常和肝肾糖尿病并发症方面的治疗益处.
