血清素能神经传递与几种精神疾病的侵袭有关。人类的侵略是一个连续的特征,从正常现象到病理现象。然而,5-羟色胺能神经传递的个体差异及其与健康个体攻击特征的关系仍不清楚.在这项研究中,我们探讨了5-HT2A受体在体内的可用性与健康参与者的攻击特征之间的关系.33名健康参与者接受了3特斯拉磁共振成像和正电子发射断层扫描(PET)与[11C]MDL100907,5-HT2A受体的选择性放射性配体。为了量化5-HT2A受体的可用性,结合电位(BPND)是使用简化的参考组织模型的基函数实现得出的,以小脑为参考区域。使用Buss-Perry攻击问卷评估参与者的攻击水平。以年龄和性别为协变量的基于体素的相关分析显示,在右颞中回(MTG)极中,总攻击得分与[11C]MDL100907BPND呈显着正相关,左梭状回(FUSI),右侧海马旁回,和右侧海马体。身体攻击分量表评分与左嗅皮质[11C]MDL100907BPND呈显著正相关,左眶额上回(SFG),右前扣带回和副带回,左轨道内侧SFG,左直回,左MTG,左颞下回,和左角回.在双侧SFG中,言语攻击子量表得分与[11C]MDL100907BPND呈显着正相关,右内侧SFG,左FUSI,和右MTG杆。总的来说,我们的研究结果表明,在健康个体中,攻击行为特征与体内5-HT2A受体的可利用性之间存在正相关.未来的研究应纳入多模式神经成像,以研究5-HT2A受体介导的信号传导的下游效应,并整合与攻击特征相关的分子和系统水平信息。
Serotonergic neurotransmission has been associated with aggression in several psychiatric disorders. Human aggression is a continuum of traits, ranging from normal to pathological phenomena. However, the individual differences in serotonergic neurotransmission and their relationships with aggression traits in healthy individuals remain unclear. In this study, we explored the relationship between 5-HT2A receptor availability in vivo and aggression traits in healthy participants. Thirty-three healthy participants underwent 3-Tesla magnetic resonance imaging and positron emission tomography (PET) with [11C]MDL100907, a selective radioligand for 5-HT2A receptors. To quantify 5-HT2A receptor availability, the binding potential (BPND) was derived using the basis function implementation of the simplified reference tissue model, with the cerebellum as the reference region. The participants\' aggression levels were assessed using the Buss-Perry Aggression Questionnaire. The voxel-based correlation analysis with age and sex as covariates revealed that the total aggression score was significantly positively correlated with [11C]MDL100907 BPND in the right middle temporal gyrus (MTG) pole, left fusiform gyrus (FUSI), right parahippocampal gyrus, and right hippocampus. The physical aggression subscale score had significant positive correlations with [11C]MDL100907 BPND in the left olfactory cortex, left orbital superior frontal gyrus (SFG), right anterior cingulate and paracingulate gyri, left orbitomedial SFG, left gyrus rectus, left MTG, left inferior temporal gyrus, and left angular gyrus. The verbal aggression subscale score showed significant positive correlations with [11C]MDL100907 BPND in the bilateral SFG, right medial SFG, left FUSI, and right MTG pole. Overall, our findings suggest the possibility of positive correlations between aggression traits and in vivo 5-HT2A receptor availability in healthy individuals. Future research should incorporate multimodal neuroimaging to investigate the downstream effects of 5-HT2A receptor-mediated signaling and integrate molecular and systems-level information in relation to aggression traits.