PDF(Pubmed)
Abstract：
Psychedelics are quite unique among drugs that impact the central nervous system, as a single administration of a psychedelic can both rapidly alter subjective experience in profound ways and produce sustained effects on circuits relevant to mood, fear, reward, and cognitive flexibility. These remarkable properties are a direct result of psychedelics interacting with several key neuroreceptors distributed across the brain. Stimulation of these receptors activates a variety of signaling cascades that ultimately culminate in changes in neuronal structure and function. Here, we describe the effects of psychedelics on neuronal physiology, highlighting their acute effects on serotonergic and glutamatergic neurotransmission as well as their long-lasting effects on structural and functional neuroplasticity in the cortex. We propose that the neurobiological changes leading to the acute and sustained effects of psychedelics might be distinct, which could provide opportunities for engineering compounds with optimized safety and efficacy profiles.
摘要：
迷幻药在影响中枢神经系统的药物中是非常独特的，作为一个迷幻药的单一管理可以迅速改变主观经验的深刻的方式，并产生持续的影响电路相关的情绪，恐惧,奖励,和认知灵活性。这些非凡的特性是迷幻药与分布在大脑中的几个关键神经受体相互作用的直接结果。这些受体的刺激激活各种信号级联,最终导致神经元结构和功能的变化。这里,我们描述了迷幻药对神经元生理的影响，强调它们对5-羟色胺能和谷氨酸能神经传递的急性影响，以及它们对皮质结构和功能神经可塑性的长期影响。我们认为，导致迷幻药急性和持续影响的神经生物学变化可能是不同的，这可以为具有优化的安全性和有效性特征的工程化合物提供机会。预计《生理学年度回顾》的最终在线出版日期，第86卷是2024年2月。请参阅http://www。annualreviews.org/page/journal/pubdates的订正估计数。
