■我们旨在在本研究中评估纤溶酶-α2-纤溶酶抑制剂复合物在恶性肿瘤和静脉血栓栓塞(VTE)患者中的诊断价值。
■共选择58例确诊为恶性肿瘤和VTE的患者,并在VTE诊断后24小时内收集其血浆样本。我们还选择了60例同时住院且影像学检查后未发生VTE的恶性肿瘤患者。在入院后24小时内收集他们的血浆样本,并与VTE组的血浆样本进行比较,以了解纤溶酶-α2-纤溶酶抑制剂(PIC)的水平,凝血酶-抗凝血酶复合物(TAT),组织型纤溶酶原激活物-抑制剂复合物(tPAI-C),和血栓调节蛋白(TM)。我们使用受试者操作特征(ROC)曲线来评估每个指标对伴有VTE的恶性肿瘤的诊断效能。
■PIC,TAT,与无血栓形成的恶性肿瘤组相比,恶性肿瘤和VTE组的tPAI-C明显更高(分别为p=0.010,p=0.001和p=0.003)。相比之下,我们发现两组之间的TM水平没有显着差异(p=0.483)。PIC曲线下面积(AUC),TAT,恶性肿瘤和VTE患者的tPAI-C分别为0.852、0.636和0.655,证明对那些患有VTE的癌症患者的诊断价值。PIC在恶性肿瘤和VTE患者中的诊断效率最高。而TM的AUC为0.537,因此其对VTE并发恶性肿瘤的诊断价值有限。
■PIC对恶性肿瘤患者VTE的早期诊断具有足够的价值。HIPPOKRATIA2023,27(2):37-40.
UNASSIGNED: We aimed to evaluate in this study the diagnostic value of the plasmin-α2-plasmin inhibitor complex in patients with malignant tumors and venous thromboembolism (VTE).
UNASSIGNED: A total of 58 patients with confirmed malignant tumors and VTE were selected, and their plasma samples were collected within 24 hours after VTE diagnosis. We also selected 60 patients with malignant tumors who were hospitalized at the same time and did not have VTE following imaging examination. Their plasma samples were collected within 24 hours after admission and were compared to those of the VTE group concerning the levels of plasmin-α2-plasmin inhibitor (PIC), thrombin-antithrombin complex (TAT), tissue-type plasminogen activator-inhibitor complex (tPAI-C), and thrombomodulin (TM). We used the receiver operator characteristic (ROC) curve to evaluate the diagnostic efficacy of each index regarding malignant tumors accompanied by VTE.
UNASSIGNED: PIC, TAT, and tPAI-C were significantly higher in the group with malignant tumors and VTE compared to the group with malignant tumors without thrombosis (p =0.010, p =0.001, and p =0.003, respectively). In contrast, we found no significant difference in TM levels between the two groups (p =0.483). The area under the curve (AUC) of PIC, TAT, and tPAI-C regarding patients with malignant tumors and VTE was 0.852, 0.636, and 0.655, respectively, demonstrating diagnostic values for those cancer patients suffering VTE. PIC had the highest diagnostic efficiency in those patients with malignant tumors and VTE, while the AUC of TM was 0.537, so its diagnostic value for VTE-complicated malignant tumors was limited.
UNASSIGNED: PIC has a sufficient value for the early diagnosis of VTE in patients with malignant tumors. HIPPOKRATIA 2023, 27 (2):37-40.