关键词: Chinese herb monomer Chinese patent medicine adjuvant therapy adverse effects drug resistance malignant tumors

来  源:   DOI:10.3389/fonc.2024.1412370   PDF(Pubmed)

Abstract:
Malignant tumors are complex systemic chronic diseases and one of the major causes of human mortality. Targeted therapy, chemotherapy, immunotherapy, and radiotherapy are examples of mainstream allopathic medicine treatments that effective for intermediate and advanced malignant tumors. The ongoing use of conventional allopathic medicine has resulted in adverse responses and drug resistance, which have hampered its efficacy. As an important component of complementary and alternative medicine, Chinese medicine has been found to have antitumor effects and has played an important role in enhancing the therapeutic sensitivity of mainstream allopathic medicine, reducing the incidence of adverse events and improving immune-related functions. The combined application of adjuvant Chinese medicine and mainstream allopathic medicine has begun to gain acceptance and is gradually used in the field of antitumor therapy. Traditional natural medicines and their active ingredients, as well as Chinese patent medicines, have been proven to have excellent therapeutic efficacy and good safety in the treatment of various malignant tumors. This paper focuses on the mechanism of action and research progress of combining the above drugs with mainstream allopathic medicine to increase therapeutic sensitivity, alleviate drug resistance, reduce adverse reactions, and improve the body\'s immune function. To encourage the clinical development and use of Chinese herb adjuvant therapy as well as to provide ideas and information for creating safer and more effective anticancer medication combinations, the significant functions of Chinese herb therapies as adjuvant therapies for cancer treatment are described in detail.
摘要:
恶性肿瘤是复杂的全身性慢性疾病,是人类死亡的主要原因之一。靶向治疗,化疗,免疫疗法,和放射疗法是对中晚期恶性肿瘤有效的主流对抗疗法。常规对抗疗法的持续使用导致了不良反应和耐药性,这阻碍了它的功效。作为补充和替代医学的重要组成部分,已发现中药具有抗肿瘤作用,在增强主流对症药物的治疗敏感性方面发挥了重要作用,降低不良事件的发生率和改善免疫相关功能。辅助中药与主流对症药物的联合应用已开始被接受,并逐步应用于抗肿瘤治疗领域。传统天然药物及其活性成分,以及中成药,已被证明在各种恶性肿瘤的治疗中具有优异的治疗效果和良好的安全性。本文重点介绍了上述药物与主流对抗疗法药物结合提高治疗敏感性的作用机制及研究进展,缓解耐药性,减少不良反应,提高身体的免疫功能。鼓励临床开发和使用中药辅助疗法,并为创建更安全,更有效的抗癌药物组合提供思路和信息,详细描述了中草药疗法作为癌症治疗辅助疗法的重要功能。
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