PDF(Pubmed)
Abstract：
UNASSIGNED: Biliary tract cancer stands as a prevalent illness, posing significant risks to human health, where immune cells are pivotal in both its development and recovery processes. Due to the diverse functionalities exhibited by different immune cell phenotypes within the organism, and the relatively limited research on their relationship with biliary tract cancer, this study employed Mendelian randomization (MR) to explore their potential association, thereby aiding in a better understanding of the causal link between immune cell phenotypes and biliary tract cancer.
UNASSIGNED: In this study, the causative association of 731 immunophenotype with biliary tract cancer was established using publicly accessible genome-wide association study (GWAS) genetic data through two-sample MR analysis. Sensitivity analyses assess horizontal pleiotropy and heterogeneity of the study findings.
UNASSIGNED: Among the 731 immunophenotypes examined, a total of 26 immune cell phenotypes were found to exhibit positive results, indicating a significant association with the risk of biliary tract cancer. We confirmed that among these 26 types of immune cells, there are primarily 13 types of B cells; three types of classical dendritic cells (CDCs), including CD80 on myeloid DC, HLA DR on myeloid DC, and Myeloid DC %DC; one type of mature stage T cell,CD4RA on TD CD4+; six types of regulatory T cells; and three types of myeloid cells.
UNASSIGNED: In this study, the causative association of 731 immunophenotype with biliary tract cancer was established using publicly accessible genome-wide association study (GWAS) genetic data through two-sample MR analysis. Sensitivity analyses assess horizontal pleiotropy and heterogeneity of the study findings.
UNASSIGNED: Among the 731 immunophenotypes examined, a total of 26 immune cell phenotypes were found to exhibit positive results, indicating a significant association with the risk of biliary tract cancer. We confirmed that among these 26 types of immune cells, there are primarily 13 types of B cells; three types of classical dendritic cells (CDCs), including CD80 on myeloid DC, HLA DR on myeloid DC, and Myeloid DC %DC; one type of mature stage T cell,CD4RA on TD CD4+; six types of regulatory T cells; and three types of myeloid cells.
摘要：
■胆道癌是一种普遍的疾病，对人类健康构成重大风险，免疫细胞在其发育和恢复过程中都至关重要。由于生物体内不同免疫细胞表型表现出的不同功能，以及对它们与胆道癌关系的相对有限的研究，这项研究采用孟德尔随机化(MR)来探索它们的潜在关联，从而有助于更好地了解免疫细胞表型与胆道癌之间的因果关系。
■在这项研究中，使用可公开获取的全基因组关联研究(GWAS)遗传数据,通过双样本MR分析,确定了731种免疫表型与胆道癌的因果关系.敏感性分析评估研究结果的水平多效性和异质性。
■在所检查的731种免疫表型中，共发现26种免疫细胞表型表现出阳性结果，表明与胆道癌风险显著相关。我们证实在这26种免疫细胞中,主要有13种类型的B细胞；三种类型的经典树突状细胞（CDCs），包括髓样DC上的CD80，髓样DC上的HLADR，和髓样DC%DC；一种成熟阶段T细胞，TDCD4+上的CD4RA;六种类型的调节性T细胞;和三种类型的骨髓细胞。
■在这项研究中，使用可公开获取的全基因组关联研究(GWAS)遗传数据,通过双样本MR分析,确定了731种免疫表型与胆道癌的因果关系.敏感性分析评估研究结果的水平多效性和异质性。
■在所检查的731种免疫表型中，共发现26种免疫细胞表型表现出阳性结果，表明与胆道癌风险显著相关。我们证实在这26种免疫细胞中,主要有13种类型的B细胞；三种类型的经典树突状细胞（CDCs），包括髓样DC上的CD80，髓样DC上的HLADR，和髓样DC%DC；一种成熟阶段T细胞，TDCD4+上的CD4RA;六种类型的调节性T细胞;和三种类型的骨髓细胞。
