背景与目的前列腺,在男性生殖系统中起着至关重要的作用,具有复杂的结构和功能。前列腺扩大,通常是良性的,但偶尔是恶性的,带来了重大的健康问题,特别是在老龄化人口中。前列腺特异性抗原(PSA)作为一个重要的生物标志物,反映前列腺结构的变化并帮助诊断分层。升高的PSA水平与前列腺病理学和标准分级系统(例如Gleason分级)相关,有助于指导治疗决策。本研究旨在探讨前列腺肿大之间的相关性,PSA水平,和格里森等级,特别是在印度的背景下。材料和方法本研究在病理学系进行了一年半的时间,Rajendra医学科学研究所,兰契,并涉及100例临床前列腺肿大。临床数据,包括年龄,症状,和相关功能,被收集,并对活检标本进行组织病理学分析。使用MicrosoftExcel和SPSSStatistics版本20.0(IBMCorp.,Armonk,NY).结果我们的研究确定了几种因素与前列腺状况之间的可能联系。非素食饮食显示出与腺癌患病率增加的潜在关联(p=0.179)。尿液症状,如犹豫,不完全排尿,保留,频率,尿急在男性腺癌患者中更为常见(p<0.05)。此外,骨痛和直肠指检(DRE)异常与腺癌密切相关(p<0.001)。不出所料,年龄与前列腺重量和PSA水平呈正相关(p<0.01)。有趣的是,骨痛与其他前列腺症状的可能性较低相关(p=0.023).结论我们的研究结果为与前列腺病理相关的临床因素提供了关键的见解,并强调了对这些患者的全面诊断方法的必要性。整合临床评估和组织病理学评估。
Background and objective The prostate gland, which plays a crucial role in the male reproductive system, has a complex structure and function. Prostate enlargement, often benign but occasionally malignant, poses significant health concerns, particularly in aging populations. Prostate-specific antigen (PSA) serves as a vital biomarker, reflecting changes in prostate architecture and aiding diagnostic stratification. Elevated PSA levels correlate with prostate pathology and standard grading systems such as Gleason grading help guide treatment decisions. This study aimed to investigate the correlation between prostate enlargement, PSA levels, and Gleason grades, particularly within the Indian context. Materials and methods This study was conducted over one and a half years at the Department of Pathology, Rajendra Institute of Medical Sciences, Ranchi, and involved 100 cases of clinically enlarged prostates. Clinical data, including age, symptoms, and relevant features, were collected, and histopathological analysis was performed on biopsy specimens. Statistical analysis was conducted using Microsoft Excel and SPSS Statistics version 20.0 (IBM Corp., Armonk, NY). Results Our study identified possible links between several factors and prostate conditions. Non-vegetarian diets showed a potential association with increased adenocarcinoma prevalence (p = 0.179). Urinary symptoms like hesitancy, incomplete voiding, retention, frequency, and urgency were significantly more common in men with adenocarcinoma (p<0.05). Additionally, bone pain and abnormal digital rectal examination (DRE) findings strongly correlated with adenocarcinoma (p<0.001). As expected, age showed a positive correlation with prostate weight and PSA levels (p<0.01). Interestingly, bone pain was associated with a lower likelihood of other prostate symptoms (p = 0.023). Conclusions Our findings provide key insights into the clinical factors associated with prostate pathology and highlight the need for a comprehensive approach to diagnosis in these patients, integrating clinical evaluation and histopathological assessment.