histopathological analysis

组织病理学分析
  • 文章类型: Case Reports
    腹膜后囊肿,一种罕见的手术现象,由于其典型的无症状性质,目前的诊断挑战。一名62岁的男性,有4个月的腹胀史和打嗝增加。经临床检查,一个柔软的,扩张,显示出无触痛的腹部,可触及的肿块从上腹部区域延伸至脐带以下3厘米。影像学显示腹膜后无强化病变14.6cm×15.8cm×16.4cm,压迫右输尿管导致轻度右肾积水.多发性胆囊结石,脐疝,与肾上腺相关的脂肪瘤性病变也被发现。腹腔镜腹膜后膀胱切除术,胆囊切除术,并进行脐疝修补术。术中,发现150毫升腹水和1200毫升囊液。这个病例突出了腹膜后囊肿的复杂临床表现,强调手术探查的必要性。成功的腹腔镜治疗有助于不断发展对最佳治疗策略的理解。
    Retroperitoneal cysts, a rare surgical phenomenon, present diagnostic challenges due to their typically asymptomatic nature. A 62-year-old male presented with a 4-month history of abdominal distension and increased burping. Upon clinical examination, a soft, distended, nontender abdomen with a palpable mass extending from the epigastric region to 3 cm below the umbilicus was revealed. Imaging revealed a 14.6 cm × 15.8 cm × 16.4 cm nonenhancing retroperitoneal lesion, compressing the right ureter and causing mild right hydronephrosis. Multiple gall bladder calculi, an umbilical hernia, and lipomatous lesions associated with adrenal glands were also discovered. Laparoscopic retroperitoneal cystectomy, cholecystectomy, and umbilical hernia repair were performed. Intraoperatively, 150 ml ascitic fluid and 1200 ml cystic fluid were found. This case highlights the intricate clinical presentation of a retroperitoneal cyst, emphasizing the need for surgical exploration. Successful laparoscopic management contributes to the evolving understanding of optimal treatment strategies.
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  • 文章类型: Case Reports
    炎性肌纤维母细胞瘤由于缺乏特异性指标而难以诊断。我们描述了原发性腹膜的炎性肌纤维母细胞瘤的诊断挑战性病例。
    患者是一名25岁的男性,在我们医院就诊,患有下腹痛。计算机断层扫描显示膀胱上方直径80毫米的肿块。这被怀疑是脐带血肿瘤。既然不能排除恶性肿瘤,手术是有计划的。这揭示了由腹膜引起的脆弱肿瘤。移除后,通过组织病理学分析,该肿瘤被诊断为炎性肌纤维母细胞瘤.
    我们描述了通过组织病理学诊断为原发性腹膜的炎性肌纤维母细胞瘤的病例。腹壁和膀胱前肿瘤的鉴别诊断应考虑炎性肌纤维母细胞瘤。
    UNASSIGNED: Inflammatory myofibroblastic tumors are difficult to diagnose because of the lack of specific indicators. We describe a diagnostically challenging case of an inflammatory myofibroblastic tumor primary to the peritoneum.
    UNASSIGNED: The patient was a 25-year-old male who presented at our hospital with lower abdominal pain. Computed tomography revealed a mass lesion 80 mm in diameter just above the bladder. This was suspected to be a bleeding tumor of the urachus. Since malignancy could not be ruled out, surgery was planned. This revealed a fragile tumor arising from the peritoneum. Following its removal, the tumor was diagnosed by histopathological analysis as an inflammatory myofibroblastic tumor.
    UNASSIGNED: We describe a case of inflammatory myofibroblastic tumor primary to the peritoneum diagnosed by histopathology. Inflammatory myofibroblastic tumor should be considered in the differential diagnosis of abdominal wall and anterior bladder tumors.
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  • 文章类型: Case Reports
    肾血管平滑肌脂肪瘤是由脂肪组织组成的良性间质瘤,平滑肌,和血管。尽管是良性的,肿瘤有时具有侵袭性,局部和静脉延伸。这里,我们介绍了一个48岁的女性,她腹部有一个肿块两个月,最初很小,并逐渐增加与疼痛相关的大小。腹部-骨盆的超声检查显示,左肾引起的异质性病变不明确,其中几乎没有低回声和钙化灶。对比增强计算机断层扫描显示外生性肿块病变,中央瘢痕和钙化13x11cm,表明肾细胞癌。基于良性的性质和良好的封装,患者接受了左侧根治性肾切除术。然而,最终的组织学评估与肾血管平滑肌脂肪瘤一致.
    Renal angiomyolipoma is a benign mesenchymal tumor composing adipose tissue, smooth muscle, and blood vessels. Despite being benign, the tumor sometimes can be aggressive with a locoregional and venous extension. Here, we present a case of a 48-year-old female who presented with a lump in the abdomen for two months, which was initially small and gradually increased in size associated with pain. Ultrasound of abdomen-pelvis showed ill-defined heterogeneous lesion arising from left kidney showing few hypoechoic and calcific focus within it. Contrast-enhanced computed tomography suggested an exophytic mass lesion with a central scar and calcification measuring 13 x 11 cm indicating renal cell carcinoma. Based on the benign nature and being well encapsulated, the patient was taken up for a left radical nephrectomy. However, the final histologic assessment concurred with renal angiomyolipoma.
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  • 文章类型: Case Reports
    目的:报告在CarlosAndradeMarin医院治疗前列腺易逝癌患者的临床监测和治疗情况。
    方法:我们回顾了在CarlosAndradeMarin医院接受机器人辅助前列腺癌根治术的148例患者的病历。这些病例在2016年1月至2018年12月期间报告。诊断是通过用12个圆柱体进行经直肠前列腺活检来进行的。该样本由病理学家研究,该病理学家回顾了根治性前列腺切除术。
    结果:三例患者患有前列腺渐逝癌,这些病例显示Gleason6(3+3)前列腺癌。两名患者接受了新辅助激素治疗,另一名患者在活检期间使用的12个圆柱体中有1个出现了轻微的肿瘤侵袭。在这三种情况下,样品分析后,没有残留肿瘤的证据.因此,它们被归类为pT10。
    结论:在这项研究中,从所研究的患者中获得的结果表明,前列腺渐逝癌的发生率为2%。这些不同因素的组合,如临床状态,术前PSA,正气缸的数量和侵入百分比,此外,在根治性前列腺切除术前使用新辅助激素治疗可以帮助预测前列腺渐逝癌。
    OBJECTIVE: To report the treatment and clinical monitoring in patients with prostatic evanescent carcinoma at Hospital Carlos Andrade Marin.
    METHODS: We reviewed the medical records of 148 patients undergoing by robot-assisted radical prostatectomy in Carlos Andrade Marin hospital. The cases reported between January 2016 to December 2018. The diagnosis was carried by taking a transrectal prostate biopsy with 12 cylinders. This samples are studied by the pathologist who reviews the radical prostatectomy surgery.
    RESULTS: Three patients had prostatic evanescent carcinoma, which those cases showed Gleason 6 (3+3) prostate cancer. Two received neoadjuvant hormone therapy and the other patient presented minor tumor invasion in 1 out of 12 cylinders used during the biopsy. In the three cases, after the sample analysis, there was no residual tumor evidence. Therefore, they were classified as pT10.
    CONCLUSIONS: In this study, the results obtained from the patients studied presents the incidence of prostatic evanescent carcinoma is 2%. The combination of these different factors such as clinical status, preoperative PSA, number of positive cylinders and the invasion percentage, additionally to the usage of neoadjuvant hormone therapy prior the radical prostatectomy can help to predict evanescent carcinoma of the prostate.
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  • 文章类型: Journal Article
    水产品是世界上必需的蛋白质来源之一,其质量和安全性受到细菌性疾病的威胁。本研究调查了细菌感染对主要食用部位的可能影响,肌肉,在小龙虾感染了freundii柠檬酸杆菌的情况下。组织病理学分析证实,小龙虾对弗氏梭菌敏感,肌肉是靶器官之一。转录组结果显示细胞间连接受损,肌动蛋白表达下调,和抑制代谢途径。此外,转录组学结果表明,弗氏梭菌主要影响肌肉结构和营养。随后的验证实验证实了弗氏梭菌感染的小龙虾肌肉的结构损伤和营养损失。此外,腐败试验表明,弗氏梭菌不会加速肌肉腐败,细菌对食品安全的影响有限。因此,虽然弗龙地氏梭菌可能不是一种特定的腐败细菌,它仍然影响小龙虾肌肉的食用味道和营养价值。这项研究的结果可能有助于进一步研究弗氏梭菌感染,并为细菌感染对水产品的不利影响提供警告。
    Aquatic products are one of the world\'s essential protein sources whose quality and safety are threatened by bacterial diseases. This study investigated the possible effects of bacterial infection on the main edible part, the muscle, in the case of crayfish infected with Citrobacter freundii. The histopathological analysis confirmed that crayfish was sensitive to C. freundii and muscle was one of the target organs. The transcriptome results showed impaired intercellular junctions, downregulation of actin expression, and inhibition of metabolic pathways. Furthermore, transcriptomic results suggest that C. freundii mainly affect muscle structure and nutrition. Subsequent validation experiments confirmed structural damage and nutrient loss in C. freundii infected crayfish muscle. Besides, the spoilage tests showed that C. freundii did not accelerate muscle spoilage and the bacteria had a limited impact on food safety. Therefore, although C. freundii may not be a specific spoilage bacterium, it still affects the edible taste and nutritional value of crayfish muscle. The findings of this study might contribute to further research on C. freundii infection and provide a warning about the adverse effects of bacterial infection on aquatic products.
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  • 文章类型: Case Reports
    多原发性恶性肿瘤(MPMTs)在恶性肿瘤患者中很少见。此外,在同一患者中存在五个MPMT是极为罕见的现象。在这种情况下,一名42岁的男性患者在16年内出现了5例异时MPMT,并且每次恶性肿瘤之间的持续时间随着疾病的进展而缩短.对这名患者进行了多学科治疗,他与癌症作斗争,直到生命结束。我们的报告为我们提供了对MPMT的新认识,当我们遇到在诊断出第一个肿瘤后出现各种无法解释的症状的癌症患者时,应该考虑这一点。
    Multiple primary malignant tumors (MPMTs) are rarely seen among the patients with malignant neoplasms. Moreover, the existence of five MPMTs in the same patient is an extremely rare phenomenon. In this case, a 42-year-old male patient developed five metachronous MPMTs within 16 years and the duration between each malignant tumor shortened with the progression of the disease. Multidisciplinary treatments were used on this patient and he fought against the cancers until the end of his life. Our report provides us with a new awareness of MPMTs, which should be considered when we come across with cancer patients who develop various unexplainable symptoms after the diagnosis of the first neoplasm.
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  • 文章类型: Case Reports
    呼吸道上皮腺瘤样错构瘤(REAH)是最近描述的实体,由良性腺体增生组成,并由假分层的呼吸上皮衬里。我们报告了一例22岁的男性患者,该患者因左侧巨大的鼻腔病变而有7年的鼻塞和头痛史。计算机断层扫描,进行了磁共振和活检,以临时诊断源自左侧下鼻甲的REAH。REAH的明确诊断是通过对切除的肿块进行组织病理学检查得出的。我们还讨论了这些罕见病变的起源和鉴别诊断。
    Respiratory epithelial adenomatoid hamartoma (REAH) is a recently described entity consisted of benign glandular proliferations lined by pseudostratified respiratory epithelium. We report a case of a 22-year-old male patient with 7-year history of nasal obstruction and headache resulting from a huge left-sided nasal lesion. Computed tomography, magnetic resonance and biopsy were performed to make a provisional diagnosis of REAH originating from the left-sided inferior turbinate. The definitive diagnosis of REAH was made by histopathological examination of the removed mass. We also discuss the origin and differential diagnosis of these rare lesions.
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  • 文章类型: Case Reports
    上颌骨前部植入物的放置有干扰上颌骨中的鼻腭管的风险。此病例报告介绍了我们与牙种植体治疗相关的鼻腭管囊肿的经验之一。由于根部骨折,一名45岁的男子在上颌左中切牙接受了植入物。术前X光片显示无解剖异常。取出后立即植入,28个月后的影像学检查显示无症状,植入物顶端周围的椭圆形射线可透过性,似乎与鼻腭管接触。将整个损伤连同植入物的一部分一起移除。病理诊断为鼻腭管囊肿。手术期间与鼻腭管的意外接触可能会导致鼻腭管囊肿的发展。基于术前计算机断层扫描的仔细计划可以防止此类并发症。
    Placement of an anterior maxillary implant has a risk of interfering with the nasopalatine canal in the maxilla. This case report presents one of our experiences of a nasopalatine duct cyst that developed in association with a dental implant treatment. A 45-year-old man received an implant in the maxillary left central incisor due to root fracture. Preoperative radiograph indicated no anatomical abnormalities. A postextraction immediate implant was placed, and radiographic examination after 28 months revealed an asymptomatic, oval-shaped radiolucency around the apex of the implant, seemingly in contact to the nasopalatine canal. The entire lesion was removed along with a part of the implant. Histopathologically it was diagnosed as nasopalatine duct cyst. Accidental contact with the nasopalatine canal during surgery may have induced development of the nasopalatine duct cyst. Careful planning based on preoperative computed tomography scan may prevent such complications.
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  • 文章类型: Case Reports
    Myxoid adrenocortical neoplasms are rare; to our knowledge, only 56 cases have been reported in the literature. Therefore, distinguishing benign from malignant cases is challenging. Although the histopathological features of myxoid adrenocortical neoplasia have been amply demonstrated, their imaging characteristics are yet to be reported. We describe here these characteristics for such a neoplasm. Our patient, a 70-year-old male, was found to have a 3-cm left adrenal incidentaloma through a non-enhanced computed tomography. Attenuation measurements were 22 Hounsfield units on precontrast imagery, and percentage enhancement washout was 92%. Magnetic resonance imaging showed no loss of signal intensity in T1-weighted out-of-phase images, but high signal intensity on T2-weighted and diffusion-weighted images. Left adrenalectomy was performed and the pathological diagnosis was confirmed as myxoid adrenocortical neoplasm. The imaging characteristics reported here will be beneficial to the differential diagnosis of myxoid adrenocortical neoplasms based upon image analysis and will help distinguish benign from malignant neoplasms.
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