■虫媒病毒是RNA病毒,有些具有引起神经侵袭性疾病的潜力,并且对全球健康构成越来越大的威胁。
■我们的目标是识别和绘制虫媒病毒神经侵袭性疾病的各个方面,澄清关键概念,并在我们的知识范围内找出与改善全球健康有关的适当未来方向的差距。
■证据来源:使用PubMed对文献进行了范围审查,Scopus,ScienceDirect,还有Hinari.资格标准:原始数据,包括流行病学,危险因素,神经表现,神经诊断,管理,并获得了有关神经侵袭性虫媒病毒感染的预防措施。未报告原始数据的证据来源,非英语,并且未在同行评审的期刊上被删除。图表方法:所有作者对30篇摘要的初始试点样本进行了审查,并获得了κ=0.81的Cohenκ(接近完美的一致性)。两位作者使用RayyanQCRI软件手动审查记录。
■共包括171条记录。广泛的神经系统表现最常见,包括帕金森病,脑炎/脑病,脑膜炎,弛缓性脊髓炎,和格林-巴利综合征.脑部磁共振成像常显示皮质下病变,有时伴有与急性缺血一致的弥散限制。虫媒病毒的垂直传播最常继发于寨卡病毒。先天性寨卡综合征的神经系统表现,包括小头畸形,未能茁壮成长,智力残疾,和癫痫发作。脑脊液分析通常显示淋巴细胞增多症,白蛋白升高,和与血脑屏障功能障碍一致的蛋白质。
■具有神经系统表现的虫媒病毒感染导致发病率和死亡率增加。疾病的危险因素包括在虫媒病毒流行区生活和旅行,年龄,怀孕,和免疫抑制状态。神经侵袭性虫媒病毒病的治疗在很大程度上是支持性的,并且侧重于特定的神经系统并发症。需要治疗,目前,管理的基础是疾病预防和限制人畜共患病。
UNASSIGNED: Arboviruses are RNA viruses and some have the potential to cause neuroinvasive disease and are a growing threat to global health.
UNASSIGNED: Our objective is to identify and map all aspects of arbovirus neuroinvasive disease, clarify key concepts, and identify gaps within our knowledge with appropriate future directions related to the improvement of global health.
UNASSIGNED: Sources of Evidence: A scoping review of the literature was conducted using PubMed, Scopus, ScienceDirect, and Hinari. Eligibility Criteria: Original data including epidemiology, risk factors, neurological manifestations, neuro-diagnostics, management, and preventive measures related to neuroinvasive arbovirus infections was obtained. Sources of evidence not reporting on original data, non-English, and not in peer-reviewed journals were removed. Charting Methods: An initial pilot sample of 30 abstracts were reviewed by all authors and a Cohen\'s kappa of κ = 0.81 (near-perfect agreement) was obtained. Records were manually reviewed by two authors using the Rayyan QCRI software.
UNASSIGNED: A total of 171 records were included. A wide array of neurological manifestations can occur most frequently, including parkinsonism, encephalitis/encephalopathy, meningitis, flaccid myelitis, and Guillain-Barré syndrome. Magnetic resonance imaging of the brain often reveals subcortical lesions, sometimes with diffusion restriction consistent with acute ischemia. Vertical transmission of arbovirus is most often secondary to the Zika virus. Neurological manifestations of congenital Zika syndrome, include microcephaly, failure to thrive, intellectual disability, and seizures. Cerebrospinal fluid analysis often shows lymphocytic pleocytosis, elevated albumin, and protein consistent with blood-brain barrier dysfunction.
UNASSIGNED: Arbovirus infection with neurological manifestations leads to increased morbidity and mortality. Risk factors for disease include living and traveling in an arbovirus endemic zone, age, pregnancy, and immunosuppressed status. The management of neuroinvasive arbovirus disease is largely supportive and focuses on specific neurological complications. There is a need for therapeutics and currently, management is based on disease prevention and limiting zoonosis.