PDF(Pubmed)
Abstract：
UNASSIGNED: Mayaro Fever (MF) is a tropical disease caused by the Mayaro virus (MAYV), with outbreaks documented in Latin America.
UNASSIGNED: A hospital-based fever surveillance in Leticia, Colombian Amazon, collected sera from 1,460 patients aged 5-89 between December 2020 and April 2023.
UNASSIGNED: Dengue and malaria were the main diagnoses (19.4 and 5.8%, respectively), leaving 71.4% of cases unidentified after testing. Metagenomic sequencing and real-time RT-qPCR testing identified MAYV in two patients (25-year-old male and an 80-year-old female) exhibiting typical symptoms, of MF including rash, joint pain, and fever. Phylogenetics analysis of these two viruses revealed a close relationship to Peruvian strains within the MAYV D genotype.
UNASSIGNED: The study of AFI in Leticia, Colombia, identified dengue as prevalent, with malaria, COVID-19, Influenza, and Zika viruses also detected. Despite extensive testing, most cases remained unexplained until metagenomic sequencing revealed MAYV, previously unseen in Colombia but known in neighboring countries.
UNASSIGNED: This study presents the first near full-length genomes of MAYV in Colombia, highlighting the need for further seroprevalence studies and enhanced surveillance to understand and control the spread of the virus in the region.
UNASSIGNED: A hospital-based fever surveillance in Leticia, Colombian Amazon, collected sera from 1,460 patients aged 5-89 between December 2020 and April 2023.
UNASSIGNED: Dengue and malaria were the main diagnoses (19.4 and 5.8%, respectively), leaving 71.4% of cases unidentified after testing. Metagenomic sequencing and real-time RT-qPCR testing identified MAYV in two patients (25-year-old male and an 80-year-old female) exhibiting typical symptoms, of MF including rash, joint pain, and fever. Phylogenetics analysis of these two viruses revealed a close relationship to Peruvian strains within the MAYV D genotype.
UNASSIGNED: The study of AFI in Leticia, Colombia, identified dengue as prevalent, with malaria, COVID-19, Influenza, and Zika viruses also detected. Despite extensive testing, most cases remained unexplained until metagenomic sequencing revealed MAYV, previously unseen in Colombia but known in neighboring countries.
UNASSIGNED: This study presents the first near full-length genomes of MAYV in Colombia, highlighting the need for further seroprevalence studies and enhanced surveillance to understand and control the spread of the virus in the region.
摘要：
■Mayaro热（MF）是由Mayaro病毒（MAYV）引起的热带病，拉丁美洲有疫情记录。
■莱蒂西亚的医院发热监测，哥伦比亚亚马逊，在2020年12月至2023年4月之间收集了1,460名5-89岁患者的血清。
■登革热和疟疾是主要诊断（19.4%和5.8%，分别)，在测试后留下71.4%的病例身份不明。宏基因组测序和实时RT-qPCR检测在两名表现出典型症状的患者（25岁男性和80岁女性）中确定了MAYV，MF包括皮疹，关节痛,和发烧。这两种病毒的系统发育学分析显示，MAYVD基因型与秘鲁毒株密切相关。
■在莱蒂西亚的AFI研究，哥伦比亚,确定登革热流行，疟疾，COVID-19，流感，也检测到了寨卡病毒。尽管进行了广泛的测试，大多数病例都无法解释，直到宏基因组测序显示MAYV，以前在哥伦比亚从未见过，但在邻国已知。
■这项研究提出了哥伦比亚MAYV的第一个近全长基因组，强调需要进一步的血清阳性率研究和加强监测，以了解和控制该病毒在该地区的传播。
■莱蒂西亚的医院发热监测，哥伦比亚亚马逊，在2020年12月至2023年4月之间收集了1,460名5-89岁患者的血清。
■登革热和疟疾是主要诊断（19.4%和5.8%，分别)，在测试后留下71.4%的病例身份不明。宏基因组测序和实时RT-qPCR检测在两名表现出典型症状的患者（25岁男性和80岁女性）中确定了MAYV，MF包括皮疹，关节痛,和发烧。这两种病毒的系统发育学分析显示，MAYVD基因型与秘鲁毒株密切相关。
■在莱蒂西亚的AFI研究，哥伦比亚,确定登革热流行，疟疾，COVID-19，流感，也检测到了寨卡病毒。尽管进行了广泛的测试，大多数病例都无法解释，直到宏基因组测序显示MAYV，以前在哥伦比亚从未见过，但在邻国已知。
■这项研究提出了哥伦比亚MAYV的第一个近全长基因组，强调需要进一步的血清阳性率研究和加强监测，以了解和控制该病毒在该地区的传播。
