PDF(Pubmed)
Abstract：
UNASSIGNED: Mayaro fever is an emerging viral disease that manifests as an acute febrile illness. The disease is self-limiting, however joint pain can persist for months leading to chronic arthralgia. There is no specific treatment available, which ultimately leads to socioeconomic losses in populations at risk as well as strains to the public health systems.
UNASSIGNED: We reviewed the candidate treatments proposed for Mayaro virus (MAYV) infection and disease, including antiviral compounds targeting viral or host mechanisms, and pathways involved in disease development and pathogenicity. We assessed compound screening technologies and experimental infection models used in these studies and indicated the advantages and limitations of available technologies and intended therapeutic strategies.
UNASSIGNED: Although several compounds have been suggested as candidate treatments against MAYV infection, notably those with antiviral activity, most compounds were assessed only in vitro. Compounds rarely progress toin vivo or preclinical studies, and such difficulty may be associated with limited experimental models. MAYV biology is largely inferred from related alphaviruses and reflected by few studies focusing on target proteins or mechanisms of action for MAYV. Therapeutic strategies targeting pathogenic inflammatory responses have shown potential against MAYV-induced disease in vivo, which might reduce long-term sequelae.
UNASSIGNED: We reviewed the candidate treatments proposed for Mayaro virus (MAYV) infection and disease, including antiviral compounds targeting viral or host mechanisms, and pathways involved in disease development and pathogenicity. We assessed compound screening technologies and experimental infection models used in these studies and indicated the advantages and limitations of available technologies and intended therapeutic strategies.
UNASSIGNED: Although several compounds have been suggested as candidate treatments against MAYV infection, notably those with antiviral activity, most compounds were assessed only in vitro. Compounds rarely progress toin vivo or preclinical studies, and such difficulty may be associated with limited experimental models. MAYV biology is largely inferred from related alphaviruses and reflected by few studies focusing on target proteins or mechanisms of action for MAYV. Therapeutic strategies targeting pathogenic inflammatory responses have shown potential against MAYV-induced disease in vivo, which might reduce long-term sequelae.
摘要：
■Mayaro热是一种新兴的病毒性疾病，表现为急性发热性疾病。这种疾病是自我限制的，然而，关节痛可以持续数月，导致慢性关节痛。没有具体的治疗方法，这最终导致处于危险中的人群的社会经济损失以及对公共卫生系统的压力。
■我们回顾了针对Mayaro病毒（MAYV）感染和疾病提出的候选治疗方法，包括针对病毒或宿主机制的抗病毒化合物，以及与疾病发展和致病性有关的途径。我们评估了这些研究中使用的化合物筛选技术和实验性感染模型，并指出了可用技术和预期治疗策略的优势和局限性。
■尽管已经提出了几种化合物作为抗MAYV感染的候选治疗方法，特别是那些具有抗病毒活性的人，大多数化合物仅在体外评估。化合物很少进展到体内或临床前研究，这种困难可能与有限的实验模型有关。MAYV生物学在很大程度上是从相关的甲病毒中推断出来的，并且很少有针对MAYV的靶蛋白或作用机制的研究反映出来。针对致病性炎症反应的治疗策略已显示出在体内对抗MAYV诱导的疾病的潜力。这可能会减少长期后遗症。
■我们回顾了针对Mayaro病毒（MAYV）感染和疾病提出的候选治疗方法，包括针对病毒或宿主机制的抗病毒化合物，以及与疾病发展和致病性有关的途径。我们评估了这些研究中使用的化合物筛选技术和实验性感染模型，并指出了可用技术和预期治疗策略的优势和局限性。
■尽管已经提出了几种化合物作为抗MAYV感染的候选治疗方法，特别是那些具有抗病毒活性的人，大多数化合物仅在体外评估。化合物很少进展到体内或临床前研究，这种困难可能与有限的实验模型有关。MAYV生物学在很大程度上是从相关的甲病毒中推断出来的，并且很少有针对MAYV的靶蛋白或作用机制的研究反映出来。针对致病性炎症反应的治疗策略已显示出在体内对抗MAYV诱导的疾病的潜力。这可能会减少长期后遗症。
