背景:新兴研究表明,个人护理和其他消费品中的内分泌干扰化学物质(EDC)与各种不良健康影响有关,包括呼吸和生殖影响。尽管黑人比其他人群使用更多的个人护理产品,并且哮喘负担很高,对他们的消费品使用模式和相关的EDC暴露知之甚少。
目的:在110名主要患有哮喘的黑人儿童的队列中,研究最近暴露于特定消费产品和行为之间的关联。年龄8-17岁,生活在巴尔的摩,马里兰。
方法:我们量化了双酚A(BPA)的浓度,双酚S(BPS),双酚F,两种二氯苯酚,四种对羟基苯甲酸酯,三氯生,斑点尿样中的二苯甲酮-3和三氯卡班。问卷调查被用来捕捉最近(最近24小时)的消费产品使用和行为。使用多变量线性回归评估EDC与消费品使用/行为之间的关联,调整年龄,性别,种族/民族,和护理人员收入水平。效果估计表示为产品使用者与非使用者的生物标志物浓度的几何平均比率。
结果:选择EDC的浓度增加与最近使用空气清新剂有关(比例;BPA:1.9,95CI1.4-2;BPS1.7,95CI1-2.97;对羟基苯甲酸丙酯:3.0,95CI1.6-5.6),香味蜡烛(对羟基苯甲酸甲酯:2.6,95CI1.1-6.1),和香味地毯粉(2,5-二氯苯酚:2.8,95CI1.2-6.3)。此外,食用罐头食品与一些生物标志物浓度增加相关(比率:BPA:1.7,95CI1.2-2.4;BPS:2.1,95%CI:1.2-3.6)。
结论:这些发现增加了大量证据,表明最近在黑人儿童中使用某些消费品会导致接触到关注的化学物质,并可能为缓解接触干预措施提供信息。研究结果对可能面临暴露和健康差异的儿科人群和黑人儿童具有广泛的潜在健康影响。
结论:关于儿童个人护理产品的使用和消费者行为如何影响他们对内分泌干扰化学物质(EDCs)的暴露,人们知之甚少。对于经常经历许多EDC的不同暴露负担的黑人儿童来说尤其如此。这是儿童之间的一个重大的知识差距,因为他们经历了关键的生长和发展窗口,特别容易受到EDC的影响。我们的研究结果表明,低收入环境中主要是黑人儿童的消费品与EDC暴露之间存在关联。确定EDC暴露决定因素具有广泛的健康影响,因为其中许多化学物质与不利的健康风险有关。
BACKGROUND: Emerging studies suggest that endocrine disrupting chemicals (EDCs) in personal care and other consumer products are linked with various adverse health effects, including respiratory and reproductive effects. Despite Black persons using more personal care products than other demographic groups and having a high asthma burden, little is known regarding their consumer product use patterns and associated EDC exposures.
OBJECTIVE: To examine the association between recent exposure to select EDCs with specific consumer products and behaviors in a cohort of 110 predominantly Black children with asthma, ages 8-17 years, living in Baltimore City, Maryland.
METHODS: We quantified concentrations of bisphenol A (BPA), bisphenol S (BPS), bisphenol F, two dichlorophenols, four parabens, triclosan, benzophenone-3, and triclocarban in spot urine samples. Questionnaires were used to capture recent (last 24-h) consumer product use and behaviors. Associations between EDCs and consumer product uses/behaviors were assessed using multivariable linear regression, adjusting for age, gender, race/ethnicity, and caregiver income level. Effect estimates were expressed as geometric mean ratios of biomarker concentrations of product-users vs non-users.
RESULTS: Increased concentrations to select EDCs were associated with recent use of air freshener (ratios; BPA: 1.9, 95%CI 1.4-2; BPS 1.7, 95%CI 1-2.97; propyl paraben: 3.0, 95%CI 1.6-5.6), scented candles (methyl paraben: 2.6, 95%CI 1.1-6.1), and scented carpet powder (2,5-dichlorophenol: 2.8, 95%CI 1.2-6.3). Additionally, consuming canned food was associated with some increased biomarker concentrations (ratios: BPA: 1.7, 95%CI 1.2-2.4; BPS: 2.1, 95% CI: 1.2-3.6).
CONCLUSIONS: These findings add to the body of evidence suggesting that recent use of select consumer products in Black children contributes to exposure of chemicals of concern and could potentially inform exposure mitigation interventions. Findings have broad potential health implications for pediatric populations and Black children who may face exposure and health disparities.
CONCLUSIONS: Little is known about how children\'s personal care product use and consumer behaviors affect their exposures to endocrine disrupting chemicals (EDCs). This is particularly true for Black children who often experience a disparate exposure burden to many EDCs. This is a significant knowledge gap among children that are uniquely vulnerable to EDCs as they undergo critical windows of growth and development. Our findings show associations between consumer products and EDC exposures in predominantly Black children in low-income settings. Identifying EDC exposure determinants has broad health implications as many of these chemicals have been associated with adverse health risks.