内分泌干扰化学物质(EDC)可能是非传染性疾病的主要危险因素。尤其是当孩子们接触到他们的时候。这项研究的目的是评估三氯生(TCS)的尿液浓度,甲基三氯生(MTCS),三氯卡班(TCC),和2,4-二氯苯酚(2,4-DCP)及其与居住在Kerman的6-18岁儿童和青少年的人体测量和人口统计学参数的关系,伊朗,在2020年。使用GC/MS仪器测量分析物的浓度。TCS,MTCS,TCC,和2,4-DCP几何平均浓度(µg/L)分别为4.32±2.08、1.73±0.88、4.66±10.25和0.19±0.14。TCS,MTCS,TCC,和2,4-DCP显示与BMIz评分和BMI呈正相关且显着相关(p值<0.01)。TCS和MTCS有积极的一面,坚强,和实质性关联(p值<0.01,r=0.74)。腰围(WC)与所研究的分析物之间没有显着关联。此外,分析物浓度和人口统计学参数(吸烟,教育,收入,等。)总体上。在克尔曼,伊朗,目前的研究是第一个研究TCS之间的关联,MTCS,TCC,和2,4-DCP分析物以及人体测量和人口统计数据。尿TCS的水平,MTCS,TCC,2,4-DCP,在这项研究中,儿童和青少年的人体测量参数被证明有显著的相关性。然而,因为当前的研究是横断面的,并且不确定单个实验是否准确地反映了这些分析物的长期暴露,需要更多的研究来确定这些分析对儿童和青少年健康的影响。
Endocrine-disrupting chemicals (EDCs) can be a major risk factor for noncommunicable illnesses, especially when children are exposed to them. The purpose of this study was to assess the urine concentrations of triclosan (TCS), methyl triclosan (MTCS), triclocarban (TCC), and 2,4-dichlorophenol (2,4-DCP) and its association with anthropometric and demographic parameters in children and adolescents aged 6-18 living in Kerman, Iran, in 2020. A GC/MS instrument was used to measure the concentrations of the analytes. TCS, MTCS, TCC, and 2,4-DCP geometric mean concentrations (µg/L) were 4.32 ± 2.08, 1.73 ± 0.88, 4.66 ± 10.25, and 0.19 ± 0.14, respectively. TCS, MTCS, TCC, and 2,4-DCP were shown to have a positive and significant association with BMI z-score and BMI (p-value < 0.01). TCS and MTCS have a positive, strong, and substantial association (p-value < 0.01, r = 0.74). There was no significant association between the waist circumference (WC) and the analytes studied. In addition, there was a close association between analyte concentration and demographic parameters (smoking, education, income, etc.) overall. In Kerman, Iran, the current study was the first to look into the association between TCS, MTCS, TCC, and 2,4-DCP analytes and anthropometric and demographic data. The levels of urinary TCS, MTCS, TCC, 2,4-DCP, and anthropometric parameters in children and adolescents are shown to have a significant association in this study. However, because the current study is cross-sectional and it is uncertain if a single experiment accurately reflects long-term exposure to these analytes, more research is needed to determine the impact of these analyses on the health of children and adolescents.