Apelin,一种生物活性肽,可作为apelin受体(APJ)的内源性配体,在各种类型的癌症中过表达,并有助于癌细胞增殖,生存能力,迁移,血管生成,和转移,以及免疫偏差。非编码RNA(ncRNAs)调节基因表达,越来越多的证据表明ncRNAs(包括长链非编码RNAs[lncRNAs],环状RNAs[circRNAs],和microRNAs[miRNAs])和apelin在癌症中。某些miRNA可以直接靶向apelin并抑制其表达,从而抑制肿瘤生长。已经表明miR-224,miR-195/miR-195-5p,miR-204-5p,miR-631、miR-4286、miR-637、miR-4493和miR-214-3p靶向apelinmRNA并影响其在前列腺癌中的表达,肺癌,食道癌,软骨肉瘤,黑色素瘤,胃癌,神经胶质瘤,和肝细胞癌(HCC),分别。此外,circ-NOTCH1,circ-ZNF264和lncRNABACE1-AS上调apelin在胃癌中的表达,神经胶质瘤,和HCC,分别。另一方面,已显示apelin调节某些ncRNAs的表达以影响肿瘤发生。发现apelin影响circ_0000004/miR-1303、miR-15a-5p的表达,和miR-106a-5p在骨肉瘤中,肺癌,前列腺癌,分别。这篇综述解释了ncRNAs和apelin在癌症中的双向相互作用,以提供有关这种串扰的分子机制以及对癌症治疗的潜在影响的见解。
Apelin, a bioactive peptide that serves as an endogenous ligand for the
apelin receptor (APJ), is overexpressed in various types of cancers and contributes to cancer cell proliferation, viability, migration, angiogenesis, and metastasis, as well as immune deviation. Noncoding RNAs (ncRNAs) regulate gene expression, and there is growing evidence suggesting a bidirectional crosstalk between ncRNAs (including long noncoding RNAs [lncRNAs], circular RNAs [circRNAs], and microRNAs [miRNAs]) and apelin in cancers. Certain miRNAs can directly target the
apelin and inhibit its expression, thereby suppressing tumor growth. It has been indicated that miR-224, miR-195/miR-195-5p, miR-204-5p, miR-631, miR-4286, miR-637, miR-4493, and miR-214-3p target apelin mRNA and influence its expression in prostate cancer, lung cancer, esophageal cancer, chondrosarcoma, melanoma, gastric cancer, glioma, and hepatocellular carcinoma (HCC), respectively. Moreover, circ-NOTCH1, circ-ZNF264, and lncRNA BACE1-AS upregulate
apelin expression in gastric cancer, glioma, and HCC, respectively. On the other hand, apelin has been shown to regulate the expression of certain ncRNAs to affect tumorigenesis. It was revealed that
apelin affects the expression of circ_0000004/miR-1303, miR-15a-5p, and miR-106a-5p in osteosarcoma, lung cancer, and prostate cancer, respectively. This review explains a bidirectional interplay between ncRNAs and
apelin in cancers to provide insights concerning the molecular mechanisms underlying this crosstalk and potential implications for cancer therapy.