PDF(Pubmed)
Abstract：
Adipose tissue, both intricate and fundamental to physiological functions, comprises cell types, including adipocytes, pivotal in secreting bioactive peptides known as \'adipokines.\' Apelin (APLN), Visfatin (VSFTN), and Irisin (IRSN) are novel adipokines involved in regulating energy, carbohydrate, protein, and lipid metabolism. APLN acts as an endogenous ligand for G-protein-coupled receptors, VSFTN is essential in nicotinamide adenine dinucleotide (NAD) biosynthesis, and IRSN is released from skeletal muscle and adipose tissues. Their influence spans various physiological domains, including insulin resistance and sensitivity, cardiovascular functions, angiogenesis, and reproductive systems. This review focuses on the potential roles of APLN, VSFTN, and IRSN in energy regulation mechanisms related to farm animal production. Despite accumulating evidence of their significance, comprehensive understanding is still emerging, with most studies based on model organisms. Thus, there\'s a pressing need for targeted research on farm animals. Addressing these knowledge gaps could pave the way for improved health strategies, reproductive efficiency, and productivity in farm animals. Future research should focus on understanding the multifaceted interactions of these adipokines and their implications for promoting sustainable and effective animal production.
摘要：
脂肪组织,既复杂又基本的生理功能，包括细胞类型，包括脂肪细胞,在分泌被称为脂肪因子的生物活性肽中起关键作用。\'Apelin(APLN),内脂素（VSFTN），和Irisin（IRSN）是参与调节能量的新型脂肪因子，碳水化合物，蛋白质，和脂质代谢。APLN作为G蛋白偶联受体的内源性配体，VSFTN在烟酰胺腺嘌呤二核苷酸（NAD）生物合成中至关重要，IRSN从骨骼肌和脂肪组织中释放出来。他们的影响跨越了不同的生理领域，包括胰岛素抵抗和敏感性，心血管功能,血管生成,和生殖系统。这篇综述侧重于APLN的潜在作用，VSFTN,和IRSN在与农场动物生产相关的能源调节机制中。尽管积累了它们重要性的证据，全面的理解仍然存在，大多数研究都是基于模式生物。因此，迫切需要对农场动物进行有针对性的研究。解决这些知识差距可以为改进卫生战略铺平道路，生殖效率，和农场动物的生产力。未来的研究应该集中在理解这些脂肪因子的多方面相互作用及其对促进可持续和有效动物生产的影响上。
