未经授权:脂肪组织作为分泌多种脂肪因子的活跃内分泌器官,可能参与卒中的生物学机制。Vaspin,apelin,内脂素在血管疾病的调节中起重要作用。我们的目的是评估vaspin的浓度,apelin,内脂素与卒中风险相关。本研究共纳入235例中风患者(156例缺血性中风患者和79例出血性中风患者)和235例年龄和性别匹配的健康对照。建立了夹心ELISA检测血清vaspin,apelin,和visfatin水平。血清vaspin的中位数水平有统计学意义的差异,apelin,卒中病例和对照组之间的内脂素水平(vaspin:1.50vs1.07ng/ml;apelin:1.56vs1.32pg/ml;内脂素:23.40vs19.65ng/ml;所有P值<.001)。多因素logistic回归分析表明,血清vaspin和visfatin水平与卒中风险增加呈显著负相关,最高三分位数的比值比(ORs)为vaspin的2.25[95%置信区间(CI)1.38-3.67;趋势<.001的P]和visfatin的2.56(95%CI1.46-4.47;趋势<.001的P),分别,与最低的三分位数相比。较高的apelin水平与较低的卒中风险略有关联(趋势P=0.060)。我们的研究表明,更高的vaspin,apelin,内脂素水平可能与卒中风险增加有关。未来应进行必要的前瞻性队列研究以确认这种关联。
UNASSIGNED: Adipose tissue acts as an active endocrine organ secreting a number of adipokines and may be involved in biological mechanism of stroke. Vaspin,
apelin, and visfatin play important roles in the regulation of vascular disorders.Our aim was to evaluate whether the concentrations of vaspin,
apelin, and visfatin were associated with stroke risk.A total of 235 patients with stroke (156 patients with ischemic stroke and 79 patients with hemorrhagic stroke) and 235 age- and gender-matched healthy controls were included in this study. A sandwich ELISA was developed to measure the serum vaspin, apelin, and visfatin levels.There was a statistically significant difference in the median levels of serum vaspin,
apelin, and visfatin levels between stroke cases and controls (vaspin: 1.50 vs 1.07 ng/ml;
apelin: 1.56 vs 1.32 pg/ml; visfatin: 23.40 vs 19.65 ng/ml; all P values <.001). Multiple logistic regression analysis showed that, serum vaspin and visfatin levels were significantly inversely associated with increased risk of stroke, and the odds ratios (ORs) in the highest tertile were 2.25 [95% confidence interval (CI) 1.38-3.67; P for trend <.001] for vaspin and 2.56 (95% CI 1.46-4.47; P for trend <.001) for visfatin, respectively, compared with the lowest tertile. Higher
apelin levels were marginally associated with lower stroke risk (P for trend =.060).Our study indicated that higher vaspin, apelin, and visfatin levels might be associated with increased stroke risk. Necessary prospective cohort studies should be conducted to confirm this association in the future.