■尿路致病性大肠杆菌是尿路感染(UTI)的主要原因。本研究进行了系统评价和荟萃分析,以确定2012年至2022年伊朗确诊的细菌性UTI儿童中抗生素耐药的尿路致病性大肠杆菌的患病率。
■通过搜索PubMed,Scopus,谷歌学者,WebofScience,MagIran,伊朗科学信息数据库,IranMedex,伊朗信息科学与技术研究所。通过应用随机效应模型计算抗生素特异性合并患病率估计值。采用Freeman-Tukey双反正弦变换。I-平方统计量,计算Cochran的Q检验,并对采样地点的纬度进行元回归。
■文献检索到2159篇,其中包括19篇文章。抗生素耐药性最高的是多西环素,替卡西林-克拉维酸,头孢唑啉,头孢呋辛,和阿莫西林-克拉维酸,59%,57%,54%,53%,52%,分别。纬度上的Meta回归对呋喃妥因有统计学意义(P=0.05)。
■在伊朗儿童中的大多数已确认的细菌性UTI中观察到耐药的泌尿致病性大肠杆菌菌株。治疗尿路病原体最有效的抗生素是粘菌素,美罗培南,还有亚胺培南.
UNASSIGNED: Uropathogenic Escherichia coli is a major cause of urinary tract infections (UTIs). This systematic review and meta-analysis was conducted to determine the prevalence of antibiotic-resistant uropathogenic E. coli among Iranian children with confirmed bacterial UTIs from 2012 to 2022.
UNASSIGNED: A systematic review was performed by searching PubMed, Scopus, Google Scholar, Web of Science, MagIran, Iranian Scientific Information Database, IranMedex, and Iranian Research Institute for Information Science and Technology. The antibiotic-specific pooled prevalence estimates were calculated by applying a random-effects model. Freeman-Tukey Double Arcsine transformation was applied. I-squared statistic, and Cochran\'s Q test were computed and meta-regression was conducted on latitude of sampling location.
UNASSIGNED: The literature search retrieved 2159 articles, among which 19 articles were included. The highest antibiotic resistance was related to doxycycline, ticarcillin-clavulanic acid, cefazolin, cefuroxime, and amoxycillin-clavulanic acid, 59%, 57%, 54%, 53%, and 52%, respectively. Meta-regression on the latitude was statistically significant for nitrofurantoin (P=0.05).
UNASSIGNED: Resistant uropathogenic Escherichia coli strains were observed in the majority of confirmed bacterial UTIs among Iranian children. The most effective antibiotics for uropathogens were colistin, meropenem, and imipenem.