■在这项研究中,我们打算评估肠易激综合征(IBS)患者小纤维神经病变的发生情况.
■小纤维神经病(SFN)是由小Aδ和无髓C纤维变性引起的感觉神经病变。SFN表现出积极的症状,比如刺痛,燃烧,刺痛,和疼痛,和阴性症状,包括麻木,松紧度,和寒冷。SFN与其他合并症共存(例如,纤维肌痛,炎症性肠病,乳糜泻)在以前的研究中已经报道过。
■我们进行了一项横断面研究,以评估SFN和IBS的共存。要求42名IBS患者和43名健康个体完成密歇根神经病筛查仪(MNSI)问卷。结果大于3(>3)被认为是阳性。根据犹他州早期神经病变量表(UENS)检查,对MNSI问卷结果阳性的参与者进行任何神经病变体征检查。对问卷和检查结果为阳性的参与者进行了腓肠和腓浅神经传导研究(NCS)检查。正常NCS代表完整的大纤维和SFN的诊断。
■十个参与者,IBS组7例(16.7%),健康组3例(6.9%),问卷有积极的结果。四名参与者的检查呈阳性,对于正常的NCS,并被分类为SFN阳性。所有四个SFN诊断均来自IBS组。健康组中没有人被诊断为SFN。我们可以发现IBS和健康组之间关于SFN诊断的患病率的显著统计学差异(p<0.05)。
■SFN和IBS的共同出现表明以广泛的神经元损伤为特征的广泛性神经病变综合征的可能性。因此,IBS患者(以及潜在的其他慢性疼痛)的任何周围神经病变症状都应进行SFN评估,因为及时诊断和适当治疗可提高患者的生活质量.
UNASSIGNED: In this study, we intend to evaluate the occurrence of small fiber neuropathy in patients with irritable bowel syndrome (IBS).
UNASSIGNED: Small fiber neuropathy (SFN) is a sensory neuropathy that results from the degeneration of small Aδ and unmyelinated C fibers. SFN manifests positive symptoms, such as tingling, burning, prickling, and aching, and negative symptoms, including numbness, tightness, and coldness. The SFN coexistence with other comorbidities (e.g., fibromyalgia, inflammatory bowel disease, celiac disease) has been reported in previous studies.
UNASSIGNED: We conducted a cross-sectional study to assess the coexistence of SFN and IBS. Forty-two IBS patients and forty-three healthy individuals were asked to complete the Michigan Neuropathy Screening Instrument (MNSI) questionnaire. Results greater than three (>3) were considered positive. Participants with positive MNSI questionnaire results were examined for any neuropathy signs according to the Utah Early Neuropathy Scale (UENS) examination. The participants with positive results for the questionnaire and examination were checked for the sural and the superficial peroneal nerve conduction study (NCS). Normal NCS represented intact large fibers and the diagnosis of SFN.
UNASSIGNED: Ten participants, 7 (16.7 %) in the IBS group and 3 (6.9 %) in the healthy group, had positive results for the questionnaire. Four participants were positive for the examination, with normal NCS, and were classified as SFN-positive. All four SFN diagnoses were from the IBS group. No one in the healthy group was diagnosed with SFN. We could find a significant statistical difference (p<0.05) between the IBS and healthy groups regarding the prevalence of SFN diagnosis.
UNASSIGNED: The co-occurrence of SFN and IBS suggests the possibility of a generalized neuropathy syndrome characterized by widespread neuronal impairment. Thus, any peripheral neuropathy symptom in IBS patients (and potentially other chronic pain disorders) should be evaluated for SFN since timely diagnosis and proper treatment result in a better quality of life for the patients.