PDF(Pubmed)
Abstract：
Small fiber neuropathy (SFN) is a common and debilitating disease in which the terminals of small diameter sensory axons degenerate, producing sensory loss, and in many patients neuropathic pain. While a substantial number of cases are attributable to diabetes, almost 50% are idiopathic. An underappreciated aspect of the disease is its late onset in most patients. Animal models of human genetic mutations that produce SFN also display age-dependent phenotypes suggesting that aging is an important contributor to the risk of development of the disease. In this review we define how particular sensory neurons are affected in SFN and discuss how aging may drive the disease. We also evaluate how animal models of SFN can define disease mechanisms that will provide insight into early risk detection and suggest novel therapeutic interventions.
摘要：
小纤维神经病（SFN）是一种常见的和衰弱的疾病，其中小直径的感觉轴突的末端退化，产生感官损失，和许多患者的神经性疼痛。虽然大量病例可归因于糖尿病，近50%是特发性的。该疾病的一个未被重视的方面是其在大多数患者中的晚期发作。产生SFN的人类基因突变的动物模型也显示出年龄依赖性表型，表明衰老是该疾病发展风险的重要因素。在这篇综述中，我们定义了SFN中特定的感觉神经元如何受到影响，并讨论了衰老如何驱动疾病。我们还评估了SFN的动物模型如何定义疾病机制，这些机制将提供对早期风险检测的洞察力，并提出新的治疗干预措施。
