聚乙二醇(PEG)是一种具有良好生物相容性和低成本的人造聚合物,具有广泛的应用。在这项研究中,基于单分子力谱从微观角度研究了PEG单链对不同离子浓度的动态响应,揭示了超越传统传感器设计范式的独特交互。在低浓度的氯化钾下,PEG单链表现出刚性的逐渐降低,while,相反,高浓度会导致刚度逐渐增加。这种二分法是深刻理解不同离子环境下PEG构象动力学的基石。利用PEG单链对离子浓度变化的显著敏感性,我们引入创新的传感器设计思想。根植于PEG单链的适应性,这些传感器设计超越了传统应用,环境监测方面有前途的进步,healthcare,和材料科学。
Polyethylene glycol (PEG) is an artificial polymer with good biocompatibility and a low cost, which has a wide range of applications. In this study, the dynamic response of PEG single chains to different ion concentrations was investigated from a microscopic point of view based on single-molecule force spectroscopy, revealing unique interactions that go beyond the traditional sensor-design paradigm. Under low concentrations of potassium chloride, PEG single chains exhibit a gradual reduction in rigidity, while, conversely, high concentrations induce a progressive increase in rigidity. This dichotomy serves as the cornerstone for a profound understanding of PEG conformational dynamics under diverse ion environments. Capitalizing on the remarkable sensitivity of PEG single chains to ion concentration shifts, we introduce innovative sensor-design ideas. Rooted in the adaptive nature of PEG single chains, these sensor designs extend beyond the traditional applications, promising advancements in environmental monitoring, healthcare, and materials science.