%0 Journal Article
%T Exploring Novel Sensor Design Ideas through Concentration-Induced Conformational Changes in PEG Single Chains.
%A Yu M
%A Jiang C
%A Lai B
%A Zhang K
%J Sensors (Basel)
%V 24
%N 3
%D 2024 Jan 29
%M 38339600
%F 3.847
%R 10.3390/s24030883
%X Polyethylene glycol (PEG) is an artificial polymer with good biocompatibility and a low cost, which has a wide range of applications. In this study, the dynamic response of PEG single chains to different ion concentrations was investigated from a microscopic point of view based on single-molecule force spectroscopy, revealing unique interactions that go beyond the traditional sensor-design paradigm. Under low concentrations of potassium chloride, PEG single chains exhibit a gradual reduction in rigidity, while, conversely, high concentrations induce a progressive increase in rigidity. This dichotomy serves as the cornerstone for a profound understanding of PEG conformational dynamics under diverse ion environments. Capitalizing on the remarkable sensitivity of PEG single chains to ion concentration shifts, we introduce innovative sensor-design ideas. Rooted in the adaptive nature of PEG single chains, these sensor designs extend beyond the traditional applications, promising advancements in environmental monitoring, healthcare, and materials science.