■探索反映睡眠呼吸紊乱(SDB)严重程度的标志物,并调查其与青少年和年轻人心脏代谢危险因素的关系。
■参与者来自我们的SDB流行病学队列。他们接受了通宵多导睡眠图和动态血压(BP)监测。全血细胞计数,铁蛋白,高敏C反应蛋白(hs-CRP),空腹血糖,和脂质分布进行测量。多元线性回归用于检验红细胞指数(RCI)之间的关联,铁蛋白,和阻塞性呼吸暂停低通气指数(OAHI)。对患有SDB的参与者进行了亚组分析,以了解RCI和铁蛋白与血脂的关系。hs-CRP,BP。
■有88名SDB参与者和155名16-25岁的健康对照。血红蛋白(Hb;p<.001),血细胞比容(HCT;p<.001),和铁蛋白(p<.001)随着SDB严重程度的增加而升高,并与OAHI独立相关(β=1.06,p<.001;β=40.2,p<.001;β=4.89×10-3,p=.024)。在SDB的参与者中,在调整了年龄之后,性别,BMI,发现铁蛋白与低密度脂蛋白(LDL;β=0.936×10-3,p=.008)和甘油三酯(TG;β=1.08×10-3,p<.001)之间存在显着关联,以及在Hb(β=1.40,p=0.007)之间,HCT(β=51.5,p=.010)和平均动脉压(MAP)。铁蛋白(β=0.091,p=0.002),血红蛋白(β=0.975,p=0.005),和HCT(β=38.8,p=0.004)与hs-CRP独立于年龄相关,性别,BMI,血浆LDL,地图。在多变量模型中,OAHI与LDL和TG无关。
■血清铁蛋白,但不是OAHI,在SDB参与者中与LDL和TG相关,提示它是SDB患者心脏代谢风险的潜在标志物。
UNASSIGNED: To explore markers that reflect sleep-disordered breathing (SDB) severity and investigate their associations with cardiometabolic risk factors in adolescents and young adults.
UNASSIGNED: Participants were recruited from our SDB epidemiological cohort. They underwent overnight polysomnography and ambulatory blood pressure (BP) monitoring. Complete blood count, ferritin, high-sensitivity C-reactive protein (hs-CRP), fasting blood glucose, and lipid profile were measured. Multiple linear regression was used to examine the association between red cell indices (RCIs), ferritin, and obstructive apnea-hypopnea index (OAHI). Subgroup analyses on participants with SDB were performed for the association of RCIs and ferritin with lipid profile, hs-CRP, and BP.
UNASSIGNED: There were 88 participants with SDB and 155 healthy controls aged 16-25 years. Hemoglobin (Hb; p < .001), hematocrit (HCT; p < .001), and ferritin (p < .001) were elevated with increasing SDB severity and were independently associated with OAHI (β=1.06, p < .001; β=40.2, p < .001; β=4.89 × 10-3, p = .024, respectively). In participants with SDB, after adjusting for age, sex, and BMI, significant associations were found between ferritin with low-density lipoprotein (LDL; β=0.936 × 10-3, p = .008) and triglyceride (TG; β =1.08 × 10-3, p < .001), as well as between Hb (β=1.40, p = .007), HCT (β=51.5, p = .010) and mean arterial pressure (MAP). Ferritin (β=0.091, p = .002), Hb (β=0.975, p = .005), and HCT (β=38.8, p = .004) were associated with hs-CRP independent of age, sex, BMI, plasma LDL, and MAP. OAHI was not associated with LDL and TG in the multivariable models.
UNASSIGNED: Serum ferritin, but not OAHI, was associated with LDL and TG in participants with SDB, suggesting it is a potential marker of cardiometabolic risk in patients with SDB.