PDF(Pubmed)
Abstract：
Background and Objectives: The administration of iron to premature newborns is a common intervention aimed at preventing iron deficiency (ID). However, there is no consensus on the optimal timing and dosage for iron supplementation in this population. This study evaluates the effects and potential adverse outcomes of administering iron on the 7th and 21st days of life in premature infants. Materials and Methods: This research was conducted on 108 premature neonates at the \"Louis Turcanu\" Children\'s Emergency Clinical Hospital in Timisoara, Romania. The study population was divided into a control group of 48 newborns who did not receive iron supplementation and an intervention group of 60 newborns who did. The analysis utilized univariate and multivariate regression to examine binary outcomes. Results: The findings indicate that iron supplementation significantly increased the risk of anemia during the premature period at 21 days of life, as demonstrated by both univariate and multivariate regression analyses, with an odds ratio (OR) of 2.40 (95% CI, 1.01-5.68) and an adjusted odds ratio (AOR) of 2.75 (95% CI, 1.06-7.11), respectively. Contrary to expectations, iron supplementation did not significantly alter the risk of abnormal serum ferritin or iron levels at 21 days of life, according to the univariate analysis (p = 0.380 and p = 0.526, respectively). Conclusions: The observed increase in the risk of anemia without a corresponding improvement in the serum ferritin or iron levels suggests the need for further investigation into alternative strategies for iron supplementation in premature newborns.
摘要：
背景和目的：对早产儿给予铁是一种常见的干预措施，旨在预防缺铁（ID）。然而,对于该人群补铁的最佳时间和剂量尚无共识.这项研究评估了在早产儿生命的第7天和第21天施用铁的影响和潜在的不良后果。材料和方法：这项研究是在蒂米什瓦拉的“LouisTurcanu”儿童急诊临床医院对108名早产儿进行的，罗马尼亚。将研究人群分为对照组48名未接受铁补充剂的新生儿和干预组60名接受铁补充剂的新生儿。该分析利用单变量和多变量回归来检查二元结果。结果：研究结果表明，在生命的21天，补铁显著增加了早产期间的贫血风险，正如单变量和多变量回归分析所证明的那样，优势比(OR)为2.40(95%CI，1.01-5.68)，调整后优势比(AOR)为2.75(95%CI，1.06-7.11)，分别。与预期相反,补铁并没有显著改变21天的血清铁蛋白或铁水平异常的风险，根据单因素分析（分别为p=0.380和p=0.526）。结论：观察到的贫血风险增加而血清铁蛋白或铁水平没有相应改善，这表明需要进一步研究早产新生儿补铁的替代策略。
