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Abstract：
BACKGROUND: Early detection of dengue fever progression to severe form using simple measurable tests is crucial for initiating appropriate supportive therapy. This study aimed to assess whether serum ferritin is an indicator of severity in dengue patients.
METHODS: This hospital-based prospective observational study was done on 70 patients admitted in wards and intensive care unit (ICU) of Aditya Birla Memorial Hospital, Pune, India, and Jaipur Golden Hospital, Delhi, India, satisfying inclusion criteria during the study period. Dengue cases were classified as those who had non-structural protein 1 (NS1) positivity on days 2-8 and/or positive immunoglobulin M (IgM) on days 6-10, while those with other confirmed diagnoses were considered as other febrile illnesses. The outcome of this study was to see an association between serum ferritin levels and severity of illness, condition at the time of discharge/death, and the length of hospitalization.
RESULTS: Mean serum ferritin (ng/mL), platelet count (cells/mm3), and hospital stay (in days) were 1469.43±297.53, 17289.29±8254.47, and 6.01±3.90, respectively. Subjects with severe dengue had significantly higher mean serum ferritin levels and median hospital stays compared to those with non-severe dengue (p<0.05). A moderate (Pearson correlation coefficient ρ=-0.35, p=0.0027) negative correlation was found between serum ferritin level and platelet count whereas a moderate (ρ=0.50, p=0.0000) positive correlation was found between serum ferritin level and hospital stay.
CONCLUSIONS: Serum ferritin levels can be used as a tool to help differentiate between severe and non-severe dengue.
METHODS: This hospital-based prospective observational study was done on 70 patients admitted in wards and intensive care unit (ICU) of Aditya Birla Memorial Hospital, Pune, India, and Jaipur Golden Hospital, Delhi, India, satisfying inclusion criteria during the study period. Dengue cases were classified as those who had non-structural protein 1 (NS1) positivity on days 2-8 and/or positive immunoglobulin M (IgM) on days 6-10, while those with other confirmed diagnoses were considered as other febrile illnesses. The outcome of this study was to see an association between serum ferritin levels and severity of illness, condition at the time of discharge/death, and the length of hospitalization.
RESULTS: Mean serum ferritin (ng/mL), platelet count (cells/mm3), and hospital stay (in days) were 1469.43±297.53, 17289.29±8254.47, and 6.01±3.90, respectively. Subjects with severe dengue had significantly higher mean serum ferritin levels and median hospital stays compared to those with non-severe dengue (p<0.05). A moderate (Pearson correlation coefficient ρ=-0.35, p=0.0027) negative correlation was found between serum ferritin level and platelet count whereas a moderate (ρ=0.50, p=0.0000) positive correlation was found between serum ferritin level and hospital stay.
CONCLUSIONS: Serum ferritin levels can be used as a tool to help differentiate between severe and non-severe dengue.
摘要：
背景：使用简单的可测量测试早期发现登革热进展为严重形式对于启动适当的支持治疗至关重要。本研究旨在评估血清铁蛋白是否是登革热患者严重程度的指标。
方法：这项以医院为基础的前瞻性观察性研究是对AdityaBirla纪念医院病房和重症监护病房（ICU）收治的70名患者进行的，浦那,印度,斋浦尔金医院,德里,印度,在研究期间满足纳入标准。登革热病例被分类为在第2-8天具有非结构蛋白1（NS1）阳性和/或在第6-10天具有免疫球蛋白M（IgM）阳性的病例，而具有其他确诊诊断的病例被视为其他发热性疾病。这项研究的结果是观察血清铁蛋白水平与疾病严重程度之间的关系，出院/死亡时的状况，以及住院时间。
结果：平均血清铁蛋白（ng/mL），血小板计数（细胞/mm3），住院天数分别为1469.43±297.53、17289.29±8254.47和6.01±3.90。与非重度登革热患者相比，重度登革热患者的平均血清铁蛋白水平和中位住院时间明显更高（p<0.05）。血清铁蛋白水平与血小板计数之间存在中度（Pearson相关系数ρ=-0.35，p=0.0027）负相关，而血清铁蛋白水平与住院时间之间存在中度（ρ=0.50，p=0.0000）正相关。
结论：血清铁蛋白水平可用作帮助区分严重和非严重登革热的工具。
方法：这项以医院为基础的前瞻性观察性研究是对AdityaBirla纪念医院病房和重症监护病房（ICU）收治的70名患者进行的，浦那,印度,斋浦尔金医院,德里,印度,在研究期间满足纳入标准。登革热病例被分类为在第2-8天具有非结构蛋白1（NS1）阳性和/或在第6-10天具有免疫球蛋白M（IgM）阳性的病例，而具有其他确诊诊断的病例被视为其他发热性疾病。这项研究的结果是观察血清铁蛋白水平与疾病严重程度之间的关系，出院/死亡时的状况，以及住院时间。
结果：平均血清铁蛋白（ng/mL），血小板计数（细胞/mm3），住院天数分别为1469.43±297.53、17289.29±8254.47和6.01±3.90。与非重度登革热患者相比，重度登革热患者的平均血清铁蛋白水平和中位住院时间明显更高（p<0.05）。血清铁蛋白水平与血小板计数之间存在中度（Pearson相关系数ρ=-0.35，p=0.0027）负相关，而血清铁蛋白水平与住院时间之间存在中度（ρ=0.50，p=0.0000）正相关。
结论：血清铁蛋白水平可用作帮助区分严重和非严重登革热的工具。
